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Antimyeloperoxidase (MPO) Antibodies

CPT: 83520
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  • Anti-MPO Antibodies
  • pANCA-specific Antibody

Expected Turnaround Time

1 - 3 days

Related Documents

Specimen Requirements




0.6 mL

Minimum Volume

0.3 mL


Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Test Details


For diagnosis and monitoring inflammatory activity in primary systemic small vessel vasculitides. The anti-MPO-ANCA EIA is useful for confirming positive ANCA results by IFA, particularly with the pANCA pattern. Presence of anti-MPO antibodies is highly specific for idiopathic and vasculitis-associated crescentic glomerulonephritis, classic polyarteritis nodosa, Churg-Strauss syndrome, and polyangiitis overlap syndrome without renal involvement. Levels of anti-MPO are elevated during active phases of disease and lower during remission. Therefore, monitoring anti-MPO levels can aid in disease management.


Results of this assay are not diagnostic proof of the presence or absence of disease and should be used in conjunction with clinical findings and other serological tests.


Enzyme immunoassay (EIA)

Reference Interval

0.0−9.0 units/mL


De'Oliviera J, Gaskin G, Dash A, Rees AJ, Pusey CD. Relationship between disease activity and antineutrophil cytoplasmic antibody concentration in long-term management of systemic vasculitis. Am J Kidney Dis. 1995 Mar; 25(3):380-389. 7872315
Gross WL, Csernok E. Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis. Curr Opin Rheumatol. 1995 Jan; 7(1):11-19 (review). 7718417
Jennette JC, Falk RJ. Antineutrophil cytoplasmic antibodies: Discovery, specificity, disease associations and pathogenic potential. Adv Pathol Lab Med. 1995; 8:363-378.
Savige J, Gillis D, Benson E, et al. International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA). Am J Clin Pathol. 1999 Apr; 111(4):507-513. 10191771


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163840 Antimyeloperoxidase (MPO) Abs 46266-3 163842 Antimyeloperoxidase (MPO) Abs U/mL 46266-3

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