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Synonyms
- LASA
- Lipid-bound Sialic Acid
Special Instructions
Values obtained with different assay methods should not be used interchangeably in serial testing. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. This procedure does not provide serial monitoring; it is intended for one-time use only. If serial monitoring is required, please use the serial monitoring number 480129 to order.
Expected Turnaround Time
4 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Serum or plasma
Volume
2 mL
Minimum Volume
0.1 mL
Container
Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube
Collection
If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Test Details
Use
LASA is a useful adjunct in the management of a variety of malignancies. It is generally used in conjunction with other tumor markers.
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Spectrophotometry
Reference Interval
8 - 23 mg/dL
Additional Information
Elevations in blood LASA levels have been reported in patients with mammary (63%), gastroenteric (65%), pulmonary (79%), and ovarian (94%) neoplasms as well as those with leukemia (86%), lymphoma (87%), melanoma (84%), sarcoma (97%), and Hodgkin disease (91%). LASA levels can also be elevated in patients with certain benign diseases, including inflammatory disorders. Thus, like carcinoembryonic antigen (CEA), the assay for LASA does not have the specificity or sensitivity necessary for cancer detection. However, recent studies have suggested that LASA levels may be useful in monitoring the course of therapy and detecting disease recurrence in certain cancer patients. In patients with mammary, ovarian, or colorectal neoplasms, a correlation has been found between LASA concentrations and therapeutic responses. Measurement of pre- and post-treatment LASA levels is advocated for determining a baseline for therapeutic monitoring. The combination of LASA and CEA measurements in patients with mammary, colorectal, or pulmonary cancer, and LASA and cancer antigen 125 (CA 125) measurements in those with ovarian cancer may improve the accuracy of assessing therapeutic responses. Preliminary studies have demonstrated that LASA concentrations are indicative of disease status in patients with leukemia, lymphoma, or cancer of the breast, ovary, or colorectum.
References
Bhargava AK, O'Donnell AM, Birl T, et al. Plasma lipid-bound sialic acid (LSA) in cancer and noncancer patients. Clin Chem. 1984; 30:940, 36th National Meeting of the American Association for Clinical Chemistry July 29−August 3, 1984, Washington, DC.
Dnistrian AM, Schwartz MK. Lipid-associated sialic acid. Clin Chem News. 1985; 11:14.
Dnistrian AM, Schwartz MK. Lipid-bound sialic acid as a tumor marker. Ann Clin Lab Sci. 1983; 13(2):137-142. 6859805
Dnistrian AM, Schwartz MK. Plasma lipid-bound sialic acid and carcinoembryonic antigen in cancer patients. Clin Chem. 1981 Oct; 27(10):1737-1739. 7285326
Dnistrian AM, Smith C, Schwartz D, et al. Lipid-bound sialic acid as a marker in lung cancer. Clin Chem. 1985; 31:982, 37th National Meeting of the American Association for Clinical Chemistry July 32−July 26, 1985, Atlanta, Ga.
Dunzendorfer U, Katopodis N, Dnistrian AM, Stock CC, Schwartz MK, Whitmore WF Jr. Plasma lipid bound sialic acid in patients with prostate and bladder cancer. Invest Urol. 1981 Nov; 19(3):194-196. 7298291
Dwivedi C, Dixit M, Hardy, et al. Plasma sialyltransferase, total sialic acid and lipid-bound sialic acid as tumor markers. Clin Chem. 1985; 31:983, 37th National Meeting of the American Association for Clinical Chemistry July 21−July 26, 1985, Atlanta, Ga.
Erbil KM, Jones JD, Klee GG. Use and limitations of serum total and lipid-bound sialic acid concentrations as markers for colorectal cancer. Cancer. 1985; 55(2):404-409. 3965096
Horgan IE. Total and lipid-bound sialic acid levels in sera from patients with cancer. Clin Chim Acta. 1982; 118(2-3):327-331. 7055991
Katopodis N, Hirshaut Y, Geller NL, et al. Lipid-associated sialic acid test for detection of human cancer. Cancer Res. 1982; 42(12):5270-5275. 7139630
Katopodis N, Stock CC. Improved method to determine lipid-bound sialic acid in plasma or serum. Res Commun Chem Pathol Pharmacol. 1980; 30(1):171-180. 7433766
Khanderia U, Keller JH, Grossman HB, et al. Serum sialic acid is a biological marker for malignant disease. J Surg Oncol. 1983; 23(3):163-166. 6865437
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 100313 | Lipid-associated Sialic Acid | 2943-9 | 100313 | Lipid-associated Sialic Acid | mg/dL | 2943-9 |
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