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The PLG gene is sequenced using Next Generation Sequencing (NGS).
Whole blood; acceptable alternate: cheek swab (buccal swab)
Lavender-top (EDTA) tube
Invert tube 4 times to ensure adequate mixing.
Causes for Rejection
PLG is the human gene coding for the plasminogen protein. Plasminogen deficiency is the major disorder associated with mutations in PLG.
This genetic panel is designed to detect single nucleotide variants, multiple nucleotide variants, smallindels (<50bps), and large copy number variations (deletions or duplications spanning multiple exons). The panel may miss some structural variants such as inversions, translocations, medium sized deletions/duplications, and medium/large insertions; these types of structural variants are considered to be rare, and are challenging to detect for any clinical method without prior knowledge of the nature and location of the specific structural variant.Copy number assays determine the presence of zero, one, two (normal), or three plus copies (ie, it cannot distinguish four from five copies, though either would be abnormal) of the gene or gene region. This test does not detect acquired or non-hereditary disorder.
Next Generation Sequencing (NGS)