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Cytochrome P450 2C9 Genotyping Siponimod
- P450 CYP2C9
Samples sent to Monogram for testing.
Expected Turnaround Time
6 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Lavender-top (EDTA) tube or yellow-top (ACD) tube
Collect specimen in two lavender-top (EDTA) tubes or two yellow-top (ACD) tubes. Ship specimen at room temperature.
Room temperature, refrigerated, or frozen
Causes for Rejection
Quantity not sufficient for analysis; improper container
CYP2C9 genotype testing is required to determine candidacy and the appropriate maintenance dosage for siponimod before treatment initiation. Siponimod is contraindicated in patients who have a CYP2C9*3/*3 genotype. Refer to the siponimod package insert for more details.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
ThThis test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Real-time polymerase chain reaction (RT-PCR)