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Carbamazepine Sensitivity HLA Associations
- Carbamazepine Sensitivity
- HLA A*3101
- HLA A*31:01
- HLA A3101
- HLA B*1502
- HLA B*15:02
- HLA B1502
- Oxcarbazepine Sensitivity
If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.
Whole blood or buccal swabs
7 mL whole blood or 4 buccal swabs
3 mL whole blood
Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit provided by LabCorp. To obtain the buccal kit, please telephone 800-533-1037.
For collection instructions or to obtain the buccal swab kit, please telephone 800-533-1037.
Maintain whole blood at room temperature or refrigerate. Keep buccal swabs dry and at room temperature.
Causes for Rejection
Insufficient volume of DNA
To avoid possible adverse reactions, this test has been recommended for patients who may be prescribed Carbamazepine and oxcarbazepine. Two HLA alleles are associated with adverse reactions to these drugs. The alleles are HLA B*15:02, which is more common in individuals of Asian descent, and HLA A*31:01, which is more common in individuals of European descent. This test evaluates the presence or absence of these alleles.
A negative test result does not rule out an adverse reaction with the drug Carbamazepine and oxcarbazepine. Even with approproate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for retesting.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Sequence-based typing (SBT or NGS), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain a high resolution typing
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|167443||Carbamazepine Sensitivity HLA||167727||HLA-A||13298-5|
|167443||Carbamazepine Sensitivity HLA||167728||HLA-A||13298-5|
|167443||Carbamazepine Sensitivity HLA||019422||HLA-B||57979-7|
|167443||Carbamazepine Sensitivity HLA||019423||HLA-B||57979-7|
|167443||Carbamazepine Sensitivity HLA||167384||HLA Methodology||49549-9|