Growth Hormone Binding Protein

Serum

0.3 mL

0.1 mL (Note: This volume does not allow for repeat testing.)

Gel-barrier tube; red-top tube

Reduced or absent GHBP is found in GH insensitivity due to inactivating receptor binding mutations as typified by Laron dwarfism. The most clinically relevant use of GHBP measurements is to confirm suspected Laron dwarf GH insensitivity due to genetic GH receptor defect. Other forms of GH receptor insensitivity, however may have normal or high GHBP levels. The levels of GHBP may be explained by the underlying mechanism for insensitivity, accordingly, inability to dimerize, errors in the trans-membrane structure, or in downstream actions may have high or normal GHBP levels.

Studies show that GHBP levels decrease in acromegaly, with normalization on successful treatment. The converse is not true – high GHBP levels are not found associated with GH deficiency.

Results of this test are labeled for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established by the manufacturer. The result should not be used for treatment or for diagnostic purposes without confirmation of the diagnosis by another medically established diagnostic product or procedure. The performance characteristics were determined by LabCorp.

Enzyme-linked immunosorbent assay (ELISA)