Adalimumab and Anti-Adalimumab Antibody, DoseASSURE™ ADL

Adalimumab Concentration and Anti-Adalimumab Antibody

CPT: 80299; 82397
Updated on 2/19/2019
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Test Details


  • Anti-TNF-alpha Drug
  • DoseASSURE
  • Humira
  • Anti-TNF-alpha Drug
  • Humira<
  • Humira
  • Anti-TNF-alpha Drug
  • DoseASSURE
  • Humira


Monitor anti-adalimumab therapy for individuals with Crohn's disease, inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis, or other autoimmune conditions. This test provides adalimumab drug concentration levels as well as the level of anti-adalimumab antibodies.

In the absence of anti-adalimumab antibodies, the adalimumab drug level typically reflects the total adalimumab concentration in serum. In the presence if anti-adalimumab antibodies, the adalimumab level typically reflects the antibody-unbound fraction of adalimumab concentration in serum.

This assay provides clinically valid antibody results at drug levels well above treatment targets (>30 ug/mL). Failure of adalimumab therapy may not always be due to the presence of anti-adalimumab antibodies. In addition, the absence of anti-adalimumab antibodies does not guarantee positive response to treatment.


Electrochemiluminescence Immunoassay (ECLIA)

Specimen Requirements




2 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing).


Red-top tube or gel-barrier tube


Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Refrigerate or freeze

Stability Requirements



Room temperature

7 days


7 days


7 days

Causes for Rejection

Plasma specimen received


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504575 Adalimumab+Ab 503866 Adalimumab Drug Level ug/mL 74117-3
504575 Adalimumab+Ab 503867 Anti-Adalimumab Antibody ng/mL 74116-5

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