Microarray-Products of Conception (POC) Reveal® FFPE

CPT: 81229
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Test Details

Synonyms

  • aCGH
  • CGH
  • CMA
  • Microarray
  • Reveal® SNP Microarray-Products of Conception (POC)
  • SNP Array
  • WGA

Use

Detects chromosomal imbalance that may be associated with fetal loss and is ideal for detection of complete or partial molar pregnancies.

The microarray will detect DNA copy-number changes at a threshold >1Mb for deletions, >2 Mb for duplications. Also will detect copy-neutral changes associated with uniparental disomy and identity by descent.

Limitations

This assay does not detect balanced rearrangements and low level mosaicism, or tetraploidy.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Methodology

Whole genome SNP copy number microarray analysis using Molecular Inversion Probe (MIP) technology optimized for highly degraded FFPE samples.

Specimen Requirements

Specimen

Preferred fixed products of conception (POC), formalin-fixed paraffin-embedded (FFPE) tissue

Volume

One paraffin block or ten 10-micron thick section slides

Minimum Volume

Sufficient sample to obtain enough DNA to run microarray

Container

Paraffin block transport pouch

Collection

Specimen should be fixed in 10% neutral-buffered formalin or formaldehyde.

Storage Instructions

Room temperature

Causes for Rejection

Improperly embedded preparation

Clinical Information

Special Instructions

Pertinent medical findings should accompany the test request form. Please direct questions to genetic customer service at 800-345-4363.

This assay is not approved for patients of New York State physicians.

References

Wang Y, Cheng Q, Meng L, et al. Clinical application of SNP array analysis in first-trimester pregnancy loss: a prospective study. Clin Genet. 2017 Jun;91(6):849-858.27883173

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