Histopathology

CPT: 88300; 88302; 88304; 88305; 88307; 88309; 88311; 88312; 88313; 88314; 88319; 88321; 88323; 88325; 88342 (CPT codes are assigned by the pathologist when the case is complete; the codes listed here [in combination and with the appropriate multipliers] are most commonly used for histopathology.)
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Test Details

Synonyms

  • Biopsy
  • Gross and Microscopic Pathology
  • Microscopic Section
  • Pathologic Examination
  • Pathology
  • Skin Lesion(s) Tissue Examination
  • Surgical Pathology
  • Tissue Pathology

Test Includes

Gross examination only and/or gross and microscopic examination and diagnosis

Use

Histologic diagnosis

Methodology

See individual test components.

Specimen Requirements

Specimen

Tissue

Volume

Entire specimen; paraffin embedded (FFPE) tissue block(s) or slide(s) sectioned from FFPE tissue block(s) at 4-5 microns

Container

Jars of assorted size containing 10% buffered formalin

Collection

Small biopsy specimens are to be placed immediately in 10% formalin solution. Use approximately 10 to 20 times as much formalin solution as the bulk of the tissue. Small tissues such as those from bronchoscopic biopsy, bladder biopsy, and endometrium can be compromised in a short time by placing in saline or allowing to dry. The following tissues should always be placed in formalin: small skin tumors and moles; uterine curettings; cervical biopsy; breast biopsy; prostate tissue from transurethral resection (TUR); bladder tumors and calculi; nerves and ganglia; rectal polyps; ear, nose, and throat (ENT) biopsy; lymph nodes (except those to be cultured); bone tumors; intervertebral disc; gallbladder; liver biopsy; bronchoscopic biopsy; fallopian tube segments; and any biopsy from any other site not listed. Organ and larger tissue resections are to be placed in larger containers and covered with adequate amounts of formalin. Specimens such as colons, urinary bladders, and uteri require opening to expose the mucosal surfaces to formalin. Gallbladders undergo rapid degeneration; therefore, they require immediate fixation in 10% formalin solution; an incision made in the gallbladder will aid in more rapid fixation. All specimens should be sent to the pathology department as soon as convenient to expedite the processing that leads to the eventual microscopic diagnosis.

Storage Instructions

Fix in 10% buffered formalin solution.

Causes for Rejection

Lack of medical history; improper labeling; unlabeled specimen; no surgical specimen request form

Clinical Information

Special Instructions

Test request form must state operative diagnosis and source of specimen.

LabCorp test number is for tracking purposes only. Additional test numbers may be entered upon receipt of specimen(s) at the test facility.

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf