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Immunoglobulin G, Monitoring of Primary Immunodeficiency Treatment Profile
- IgG Subclasses
- Intravenous Immunoglobulin Treatment Monitoring
- Primary Immunodeficiency Treatment Monitoring
Quantitation of IgG1, IgG2, IgG3, IgG4, total IgG
Monitoring the treatment of patients with intravenous IgG infusions who exhibit primary immunodeficiency with recurrent infections
This procedure is not suitable for the measurement of samples containing rheumatoid factor, paraproteins, other circulating immune complexes (CICs), or for lipemic or hemolyzed samples due to the unpredictable degree of non-specific light scatter these sample types may generate. The results obtained from measuring IgG subclasses should not be used in assessing atopy in allergic patients.
Total IgG trough level: >800 mg/dL
Note: Maintaining trough levels of total IgG above 800 mg/dL is reported to prevent serious bacterial illness, enteroviral meningoencephalitis, and pneumonia, but target trough levels may vary with individual patient.1-3
Approximate targets for trough levels for IgG subclasses (mg/dL)4:
In the past decades, administration of exogenous pooled human immunoglobulin for intravenous use (IVIG) has become an important therapy in clinical practice. Maintaining higher trough levels (>800 mg/dL of total IgG) in order to protect patients from recurrent infections have been reported.1-3 Percentages of relative abundance of human IgG subclasses for total IgG are reported to be approximately 60% for IgG1, 32% for IgG2, 4% for IgG3, and 4% for IgG4.4
Red-top tube or gel-barrier tube
Transfer serum to a plastic transport tube.
Causes for Rejection
Gross lipemia; hemolysis
State patient's age on the test request form.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|123225||IgG, Treatment Monitoring||123226||Immunoglobulin G, Qn, Serum||mg/dL||2465-3|
|123225||IgG, Treatment Monitoring||123227||IgG, Subclass 1||mg/dL||2466-1|
|123225||IgG, Treatment Monitoring||123228||IgG, Subclass 2||mg/dL||2467-9|
|123225||IgG, Treatment Monitoring||123229||IgG, Subclass 3||mg/dL||2468-7|
|123225||IgG, Treatment Monitoring||123230||IgG, Subclass 4||mg/dL||2469-5|