VistaSeq℠ High/Moderate Risk Breast Cancer Panel

CPT: 81162; 81321; 81323; 81404; 81405(x2); 81406(x2); 81408; 81479
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Test Details


  • Familial Cancer testing
  • Hereditary Cancer testing
  • Inherited Cancer testing


This assay is intended for patients with a family history consistent with an inherited cancer syndrome.


This assay is not designed to detect deep intronic variants, balanced translocations, large inversions, mosaicism or complex genomic rearrangements. Homopolymer regions and rare polymorphisms under primer sites can affect the performance of the assay. The presence of pseudogenes can interfere with the ability to detect variants in certain genes. This assay is not intended for use in patients who have received allogeneic bone marrow transplants, as it may not reflect the germline genetic status of these patients.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


The entire coding region of a panel of genes related to hereditary cancer is examined by next generation sequencing analysis. Additionally, portions of the flanking noncoding regions are also examined. Comprehensive deletion/duplication testing is performed using microarray CGH for 8 genes, and by multiplex ligation-dependent probe amplification (MLPA) for the CHEK2 gene. Genes tested in tested in this panel include ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, STK11 and TP53. Clinically significant findings are confirmed by Sanger sequencing or qPCR. Results are reported using ACMG guidelines and nomenclature recommended by the Human Genome Variation Society (HGVS).

Specimen Requirements


Whole blood


10 mL

Minimum Volume

7 mL


Lavender-top (EDTA) tube or yellow-top (ACD) tube


Blood is collected by routine phlebotomy.

Storage Instructions

Room temperature

Causes for Rejection

Frozen or hemolyzed specimen; quantity not sufficient for analysis

Clinical Information

Special Instructions

A Hereditary Cancer Clinical Questionnaire should be submitted with all specimens. Contact CMBP genetic services at 800-345-4363 to coordinate testing.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
481452 VistaSeq HR/MR Breast Cancer 481456 Specimen Type 31208-2
481452 VistaSeq HR/MR Breast Cancer 481457 Preauthorization N/A
481452 VistaSeq HR/MR Breast Cancer 481458 Result Summary 51968-6
481452 VistaSeq HR/MR Breast Cancer 481459 Result and Interpretation 69548-6
481452 VistaSeq HR/MR Breast Cancer 481460 Recommendations 47042-7
481452 VistaSeq HR/MR Breast Cancer 481461 Additional Information 48767-8
481452 VistaSeq HR/MR Breast Cancer 481462 Methodology and Limitations 49549-9
481452 VistaSeq HR/MR Breast Cancer 481463 References 75608-0
481452 VistaSeq HR/MR Breast Cancer 481646 Director Review 72486-4
481452 VistaSeq HR/MR Breast Cancer 481647 PDF (Image) 51969-4

For Providers

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