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- COMT Genotype
COMT alleles have been associated with disease risk or drug responsiveness (e.g. early vs. late Parkinson's disease, schizophrenia, chronic pain conditions). The COMT genotype plays a role in cognition and behavioral modification (e.g. smoking cessation, modafinil responsiveness in sleep deprivation and addiction treatment), and potentially influences estrogen-related conditions (e.g. breast cancer risk when taking hormone replacement therapy, recurrent preeclampsia).
Only the 6 SNPs in question are tested; polymorphisms or some sequence variants might affect efficiency of the PCR or mini-sequencing assays. Haplotype phases are inferred based on our validation studies. Donor DNA from transplants and recent transfusions can lead to inaccurate results.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Polymerase chain reaction (PCR) and multiplex mini-sequencing
Whole blood or LabCorp buccal swab kit (buccal swab collection kit)
1 mL (Note: This volume does not allow for repeat testing).
Causes for Rejection
Frozen sample, hemolysis; incorrect collection kit