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Vedolizumab and Anti-Vedolizumab Antibody
- Anti-integrin drug
- Biological monitoring
- Immunogenicity testing
Provides serum concentrations of vedolizumab and anti-vedolizumab antibodies in order to optimize treatment and facilitate clinical decision-making.
Drug half-life should be taken into consideration when interpreting concentrations measured in non-trough collections.
Electrochemiluminescence Immunoassay (ECLIA)
In the absence of anti-vedolizumab antibodies, the vedolizumab drug level reflects the total vedolizumab concentration. In the presence of anti-vedolizumab antibodies, the vedolizumab concentration reflects the antibody-unbound fraction of vedolizumab.
The presence of vedolizumab drug, even at concentrations well above target treatment levels , does not interfere with anti-vedolizumab antibody measurement. All positive anti-vedolizumab antibody results are verified by a confirmatory test.
Serum or plasma
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum/plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.
Causes for Rejection
Gross hemolysis; gross lipemia
This test is pending NY state approval.