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Therapeutic drug management
High-pressure liquid chromatography with ultraviolet detection (HPLC/UV)
The effective concentration range of isoniazid is dependent on the minimum inhibitory concentration of the pathogen being treated. Toxic range: >20 µg/mL.
Serum or plasma
Red-top tube or green-top (heparin) tube. Gel-barrier tubes are not recommended.
Trough levels are most reproducible.
Serum or plasma should be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube.
Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.
Causes for Rejection
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