Bupropion and Hydroxybupropion, Serum or Plasma

TEST: 811083
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CPT: 80299
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Synonyms

  • Wellbutrin®
  • Zyban®

Expected Turnaround Time

1 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum or plasma, frozen

Volume

3 mL

Minimum Volume

0.6 mL

Container

Red-top (no additive) tube or green-top (heparin) tube. Gel-barrier tubes are not recommended. Storage/Transport: Custom "Transfer for Bupropion Analysis" tube containing Sodium Citrate Monobasic (PeopleSoft N° 116538)

Collection

Centrifuge within 30 minutes of collection. Transfer separated serum or plasma to the "Transfer for Bupropion Analysis" tube containing sodium citrate monobasic (white powder). Mix well. Freeze.

Storage Instructions

Freeze immediately; ship frozen on dry ice.

Patient Preparation

Trough levels are most reproducible.

Causes for Rejection

Gel-barrier tubes; specimen received not frozen; specimen not received in Bupropion Analysis Tube containing Sodium Citrate Monobasic

Test Details

Use

Therapeutic drug management

Methodology

Liquid chromatography with tandem mass spectrometry (LC/MS-MS)

Reference Interval

Bupropion: 50−100 ng/mL; hydroxybupropion: 600−2000 ng/mL

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
811083 Bupropion (Wellbutrin) 811084 Bupropion (Wellbutrin) ng/ml 6706-6
811083 Bupropion (Wellbutrin) 811085 Hydroxybupropion ng/ml 9418-5

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