Bupropion and Hydroxybupropion, Serum or Plasma

CPT: 80338
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Test Details


  • Wellbutrin®
  • Zyban®


Therapeutic drug management


Liquid chromatography with tandem mass spectrometry (LC/MS-MS)

Reference Interval

Bupropion: 50−100 ng/mL; hydroxybupropion: 600−2000 ng/mL

Specimen Requirements


Serum or plasma, frozen


3 mL

Minimum Volume

0.6 mL


Red-top (no additive) tube or green-top (heparin) tube. Gel-barrier tubes are not recommended. Storage/Transport: Custom "Transfer for Bupropion Analysis" tube containing Sodium Citrate Monobasic (PeopleSoft N° 116538)

Patient Preparation

Trough levels are most reproducible.


Centrifuge within 30 minutes of collection. Transfer separated serum or plasma to the "Transfer for Bupropion Analysis" tube containing sodium citrate monobasic (white powder). Mix well. Freeze.

Storage Instructions

Freeze immediately; ship frozen on dry ice.

Causes for Rejection

Gel-barrier tubes; specimen received not frozen


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
811083 Bupropion (Wellbutrin) 811084 Bupropion (Wellbutrin) ng/ml 6706-6
811083 Bupropion (Wellbutrin) 811085 Hydroxybupropion ng/ml 9418-5

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