Bupropion and Hydroxybupropion, Serum or Plasma

CPT: 80338
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Test Details

Synonyms

  • Wellbutrin®
  • Zyban®

Use

Therapeutic drug management

Methodology

Liquid chromatography with tandem mass spectrometry (LC/MS-MS)

Reference Interval

Bupropion: 50−100 ng/mL; hydroxybupropion: 600−2000 ng/mL

Specimen Requirements

Specimen

Serum or plasma, frozen

Volume

3 mL

Minimum Volume

0.6 mL

Container

Red-top (no additive) tube or green-top (heparin) tube. Gel-barrier tubes are not recommended. Storage/Transport: Custom "Transfer for Bupropion Analysis" tube containing Sodium Citrate Monobasic (PeopleSoft N° 116538)

Patient Preparation

Trough levels are most reproducible.

Collection

Centrifuge within 30 minutes of collection. Transfer separated serum or plasma to the "Transfer for Bupropion Analysis" tube containing sodium citrate monobasic (white powder). Mix well. Freeze.

Storage Instructions

Freeze immediately; ship frozen on dry ice.

Causes for Rejection

Gel-barrier tubes; specimen received not frozen

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
811083 Bupropion (Wellbutrin) 811084 Bupropion (Wellbutrin) ng/ml 6706-6
811083 Bupropion (Wellbutrin) 811085 Hydroxybupropion ng/ml 9418-5
811083 Bupropion (Wellbutrin) 790718 Bupropion (Wellbutrin) N/A

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