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Bupropion and Hydroxybupropion, Serum or Plasma
Therapeutic drug management
Liquid chromatography with tandem mass spectrometry (LC/MS-MS)
Bupropion: 50−100 ng/mL; hydroxybupropion: 600−2000 ng/mL
Serum or plasma, frozen
Centrifuge within 30 minutes of collection. Transfer separated serum or plasma to the "Transfer for Bupropion Analysis" tube containing sodium citrate monobasic (white powder). Mix well. Freeze.
Freeze immediately; ship frozen on dry ice.
Causes for Rejection
Gel-barrier tubes; specimen received not frozen