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Therapeutic drug management
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Therapeutic range has not been established. Poor metabolizers of cytochrome P450 2D6 (CYP2D6) substrates may have steady-state atomoxetine concentrations sixfold greater than those of extensive metabolizers.
Serum or plasma
Red-top tube or green-top (heparin) tube. Gel-barrier tubes are not recommended.
Trough levels are most reproducible.
Serum or plasma should be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube.
Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen. Specimen is stable for three days at room temperature, for seven days refrigerated, and for six months frozen.
Causes for Rejection
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|790640||Atomoxetine (Strattera), Serum||35667-5||790581||Atomoxetine||ng/ml||35667-5|