Amantadine, Serum or Plasma

CPT: 80375
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Test Details


  • Symmetrel®


Therapeutic drug management


Gas chromatography/nitrogen phosphorus detection (GC/NPD)

Reference Interval

Therapeutic range has not been established. Expected steady-state amantadine concentrations in patients receiving recommended daily dosages: 200−1000 ng/mL.

Specimen Requirements


Serum or plasma


3 mL

Minimum Volume

1.2 mL


Red-top tube or green-top (heparin) tube. Gel-barrier tubes are not recommended.

Patient Preparation

Trough levels are most reproducible.


Serum or plasma should be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube.

Storage Instructions

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.

Causes for Rejection

Gel-barrier tubes


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
808399 Amantadine (Symmetrel) 3317-5 808400 Amantadine ng/ml 3317-5

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