Alprazolam, Serum or Plasma

CPT: 80346
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Test Details


  • Niravam®
  • Xanax®


Therapeutic drug management


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

5−25 ng/mL. Note: Some patients respond well to high-dose alprazolam therapy with resultant serum concentrations 25−55 ng/mL.

Specimen Requirements


Serum or plasma


2 mL

Minimum Volume

0.5 mL


Red-top tube or green-top (heparin) tube. Gel-barrier tubes are not recommended.

Patient Preparation

Trough levels are most reproducible.


Serum or plasma should be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube.

Storage Instructions

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen. Specimen is stable for eight days at room temperature or refrigerated, and for 19 days frozen.

Causes for Rejection

Gel-barrier tubes


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
842039 Alprazolam (Xanax) 3312-6 808489 Alprazolam (Xanax) ng/mL 3312-6
842039 Alprazolam (Xanax) 3312-6 808490 Alprazolam (Xanax) N/A

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