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Diagnosis of histoplasmosis based upon detection of antigen
A negative result does not preclude a diagnosis of histoplasmosis. This assay has been documented to cross-react with Blastomyces dermatitidis, Coccidioides immitis, Paracoccidioides brasiliensis, and Penicillium marneffei. Positive tests should be confirmed in areas or patient groups where these organisms are endemic or a risk. The following substances may interfere with the assay results: caffeine; ascorbic acid; itraconazole; amphotericin B; acetaminophen; and acetylsalicylic acid.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Enzyme immunoassay (EIA)
Antigen detection may be useful in acute disease, especially in individuals also infected with HIV, who frequently have the disseminated form of histoplasmosis without detectable antibodies to the fungus. In chronic disease, antigen may not be detected due to the low fungal burden. The highest sensitivity for rapidly and accurately diagnosing histoplasmosis in patients with acute pulmonary or disseminated infection can be obtained by testing both urine and serum.
2 mL (Note: This volume allows for repeat testing).
Gel-barrier tube, red-top tube, or serum transfer tube
Collect specimen aseptically.
Maintain specimen at room temperature. Store alternatively at 2°C to 8°C.
Causes for Rejection
Insufficient specimen volume; inappropriate specimen source; inappropriate specimen collection device (ie, blood collected/submitted in an alternative blood collection tube); specimen stability exceeded; name discrepancy between the name on the specimen container and the name in the computer or on the requisition
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|183512||Histoplasma Gal'mannan Ag Ser||51753-2||183515||Histoplasma Gal'mannan Ag Ser||44525-4|
|183512||Histoplasma Gal'mannan Ag Ser||51753-2||164011||Disclaimer:||N/A|
|Reflex Table for Histoplasma Gal'mannan Ag Ser|
|Order Code||Order Name||Result Code||Result Name||UofM||Result LOINC|
|Reflex 1||183514||Histoplasma Gal'mannan Ag Qn S||183514||Histoplasma Gal'mannan Ag Qn S||ng/mL||51753-2|