Deaminated Gliadin Antibodies, IgA

CPT: 83516
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Test Details


  • DGP, IgA


Detection of gliadin antibodies aids in the diagnosis and monitoring of certain gluten-sensitive enteropathies, such as celiac disease and dermatitis herpetiformis


Enzyme immunoassay (EIA)

Additional Information

A negative IgA result in an untreated patient does not rule out gluten-sensitive enteropathies, especially when associated with IgG gliadin antibodies. This can be explained by selective IgA deficiency, a relatively frequent finding in celiac disease. False-positives are possible as other gastrointestinal disorders are known to induce circulating antigliadin antibody, mainly Crohn disease, food protein intolerance, and postinfection malabsorption.

Specimen Requirements




1 mL

Minimum Volume

0.5 mL


Red-top tube or gel-barrier tube


Specimen should be free of bacterial contamination, hemolysis, and lipemia.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Clinical Information


Burgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug;66(8):941-947.1819255
Collin P, Maki M, Keyrilainen O, Hällström O, Reunala T, Pasternack A. Selective IgA deficiency and coeliac disease. Scand J Gastroenterol. 1992 May;27(5):367-371.1529270
Kelly CP, Feighery CF, Gallagher RB, Gibney MJ, Weir DG. Mucosal and systemic IgA antigliadin antibody in celiac disease: Contrasting patterns of response in serum, saliva, and intestinal secretion. Dig Dis Sci. 1991 Jun;36(6):743-751.2032515
McMillan SA, Haughton DJ, Biggart JD, Edgar JD, Porter KG, McNeill TA. Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy. BMJ. 1991 Nov 9;303(6811):1163-1165.1747612


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
161646 Antigliadin Abs, IgA 58709-7 161652 Deamidated Gliadin Abs, IgA units 58709-7

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