Varicella Zoster Virus (VZV) Antibodies, IgG

CPT: 86787
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Test Details

Synonyms

  • Chickenpox Titers
  • Herpes Zoster Antibodies
  • VZV IgG

Use

Diagnose VZV infection; determine adult susceptibility to infection

Methodology

Chemiluminescent immunoassay (CLIA)

Reference Interval

• Negative: <135 index

• Equivocal: 135−165 index

• Positive: >165 index

Additional Information

Although most cases of varicella or zoster are clinically unambiguous, serology may be occasionally useful in the differential diagnosis of other blistering illnesses or when infection shows an unusual complication, such as hepatitis. It may also be important to establish whether an individual is susceptible when clinical history is unclear, or when varicella immune globulin may be needed, as in the immunocompromised host or cancer patient on toxic chemotherapy. Zoster is more common with aging and may occur in the face of significant antibody titers, demonstrating that cell-mediated immunity is also significant.

Specimen Requirements

Specimen

Serum

Volume

0.5 mL

Minimum Volume

0.2 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Refrigerate. Specimen is stable for two days at room temperature or seven days refrigerated. For storage longer than seven days, freeze the specimen at less than -20°C.

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
096206 Varicella-Zoster V Ab, IgG 5403-1 096210 Varicella Zoster IgG index 5403-1

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf