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- TCRB Gene Clonality Assay
This assay can be used to detect clonal T-cell receptor β-chain gene rearrangements in blood, bone marrow, and tissue specimens. The presence of a monoclonal gene rearrangement usually, but not always, reflects the presence of a T-lymphocytic neoplasm, while polyclonal gene rearrangement patterns are found in benign reactive conditions. Thus, the results of these studies can assist in the diagnosis of lymphoproliferative disorders.
This PCR assay is able to detect a clonal DNA population at the sensitivity of 5% in a background of polyclonal DNA.
Polymerase chain reaction (PCR)
Whole blood, bone marrow, formalin-fixed, paraffin-embedded (FFPE) tissue block or slides, fresh or frozen tissue
3 to 5 mL whole blood, 1 mL bone marrow, five unstained slides at 10 μM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen.
0.5 mL whole blood, 0.5 mL bone marrow, two unstained slides at 10 μM
Fresh tissue should be placed in RPMI medium or shipped frozen on dry ice. Also acceptable are small samples (eg, punch biopsies, fine-needle aspirate).
Maintain blood, bone marrow or tissue in RPMI at 2°C to 8°C, FFPE specimens at room temperature, frozen tissue at -80°C
Causes for Rejection
Frozen whole blood/bone marrow; tumor block containing no tumor tissue; broken or stained slides; quantity not sufficient for analysis
Please direct any questions regarding this test to customer service at 800-345-4363.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|480985||TCRB Gene Clonality||480986||TCRB Gene Clonality Results:||21751-3|
|480985||TCRB Gene Clonality||480987||Clonal Size:||N/A|
|480985||TCRB Gene Clonality||480989||Block Number:||N/A|
|480985||TCRB Gene Clonality||480993||Director Review:||72486-4|
|480985||TCRB Gene Clonality||480984||Methodology:||49549-9|
|480985||TCRB Gene Clonality||480994||References:||N/A|