SNP Microarray−Products of Conception (POC)/Tissue (Reveal®)

CPT: 81229
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Test Details


  • Reveal® SNP Microarray−Products of Conception (POC)/Tissue


Detects chromosomal imbalance that may be associated with fetal loss and is ideal for detection of complete or partial moles


Unable to determine genotypes on some formalin-fixed tissue (blocks/slides), allowing only genomic dosage to be determined. This assay does not detect balanced rearrangements, low-level mosaicism (<10%), or tetraploidy.


Whole genome SNP-based copy-number microarray analysis targeting 2.695 million copy-number and allele-specific genome sites

Additional Information

The microarray will detect DNA copy-number changes at a threshold >1 Mb for deletions, >2 Mb for duplications.

Specimen Requirements


Preferred nonfixed tissue or products of conception (POC)/placental villus biopsy; formalin-fixed paraffin-embedded tissue; (Samples received in fixative are subject to additional charge for histopathology processing and reporting); unstained tissue slides


>2 to 4 mm³ tissue; 10 unstained tissue slides


Sterile container containing sterile Ringer's lactate or Hanks' balanced salt solution or transport medium provided by the cytogenetics laboratory. (Do not use isotonic saline as a transport medium or urine containers for shipping.) Specialized kits are now available for POC microarray testing. To order, please contact your local LabCorp representative. PeopleSoft: 89063, Catalogue N° 39025G.


Aseptically obtain a small piece of fetal tissue that does not appear necrotic. If specimen is a POC, placental villi or membranes may be the only fetal-derived tissue available, and an effort should be made to submit these tissues rather than maternal decidua.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Quantity not sufficient for analysis; necrotic tissue submitted

Clinical Information

Special Instructions

Pertinent medical findings must accompany test request form.


Coppinger J, Alliman S, Lamb A, et al. Whole-genome microarray analysis in prenatal specimens identifies clinically significant chromosome alterations without increase in results of unclear significance compared to targeted microarray. Prenatal Diagn. 2009 Dec; 29(12):1156-1166.19795450


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510110 POC/Tissue Microarray 510112 Specimen Type 31208-2
510110 POC/Tissue Microarray 510113 # of Genotyping Targets N/A
510110 POC/Tissue Microarray 510114 Array Type N/A
510110 POC/Tissue Microarray 510116 Diagnosis 48000-4
510110 POC/Tissue Microarray 510117 Interpretation 62365-2
510110 POC/Tissue Microarray 510118 Director Review: 48672-0
510110 POC/Tissue Microarray 512123 PDF 80563-0

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