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SNP Microarray−Products of Conception (POC)/Tissue (Reveal®)
- Reveal® SNP Microarray−Products of Conception (POC)/Tissue
Detects chromosomal imbalance that may be associated with fetal loss and is ideal for detection of complete or partial moles
Unable to determine genotypes on some formalin-fixed tissue (blocks/slides), allowing only genomic dosage to be determined. This assay does not detect balanced rearrangements, low-level mosaicism (<10%), or tetraploidy.
Whole genome SNP-based copy-number microarray analysis targeting 2.695 million copy-number and allele-specific genome sites
The microarray will detect DNA copy-number changes at a threshold >1 Mb for deletions, >2 Mb for duplications.
Preferred nonfixed tissue or products of conception (POC)/placental villus biopsy; formalin-fixed paraffin-embedded tissue; (Samples received in fixative are subject to additional charge for histopathology processing and reporting); unstained tissue slides
>2 to 4 mm³ tissue; 10 unstained tissue slides
Aseptically obtain a small piece of fetal tissue that does not appear necrotic. If specimen is a POC, placental villi or membranes may be the only fetal-derived tissue available, and an effort should be made to submit these tissues rather than maternal decidua.
Maintain specimen at room temperature.
Causes for Rejection
Quantity not sufficient for analysis; necrotic tissue submitted
Pertinent medical findings must accompany test request form.