Salivary Testosterone, LC/MS-MS (Endocrine Sciences)

CPT: 84403
Print Share

Test Details

Use

Measuring testosterone in saliva can be a noninvasive alternative to diagnose and monitor patients with androgen level-related disorders. Salivary testosterone is concluded to be an established means to screen hypogonadism in adult males1 and correlates with plasma free testosterone levels.2-5 Measuring testosterone may be important for identifying women with hirsutism or polycystic ovarian syndrome (PCOS), patients with congenital adrenal hyperplasia (CAH), or males with hypogonadism.

Limitations

Salivary testosterone must be collected in an appropriate device, as some systems absorb testosterone. Validated devices are the VersiSal® device (provided by LabCorp) or a clean vial with plain saliva (2 mL). Blood in the saliva will invalidate the test because blood contains much higher levels of testosterone. Salivary testosterone is not recommended for children until reference intervals are determined.

Results of this test are for investigational purposes only. The performance characteristics of this assay have been determined by LabCorp. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Specimen Requirements

Specimen

Saliva

Volume

2 mL

Container

Saliva collection device: Specialized kits are available for salivary testing (Catalogue N° 378155G). Contact your local LabCorp representative.

Storage Instructions

Refrigerate. Stable at room temperature or refrigerated for six days. Stable frozen for seven days.

Causes for Rejection

Specimen not saliva; collected in Salivette® brand collection device

Clinical Information

Footnotes

1. Wang C, Nieschlag E, Swerdloff R, et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations. J Androl. 2009 Jan-Feb; 30(1):1-9.
2. Gavrilova N, Lindau ST. Salivary sex hormone measurement in a national, population-based study in older adults. J Gerontol B Psychol Sci Soc Sci. 2009 Nov; 64 Suppl 1: i94-i105.
3. Lee S, Kwon S, Shin HJ, et al. Quantitative measurement of salivary testosterone in Korean adults by stable isotope-dilution liquid chromatography-electrospray-tandem mass spectrometry. BMB Rep. 2010 Nov; 43(11):761-765.
4. Matsui F, Koh E, Yamamoto K, et al. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous measurement of salivary testosterone and cortisol in healthy men for utilization in the diagnosis of late-onset hypogonadism in males. Endocr J. 2009; 56(9):1083-1093.
5. Macdonald PR, Owen LJ, Wu FC, Macdowall W, Keevil BG; NATSAL team. A liquid chromatography-tandem mass spectrometry method for salivary testosterone with adult male reference interval determination. Clin Chem. 2011 May; 57(5):774-775.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
503765 Salivary Testosterone, LCMS 503769 Salivary Testosterone, LCMS pg/mL 2984-3
503765 Salivary Testosterone, LCMS 503771 Salivary Testosterone, LCMS N/A

For Providers

Please login to order a test.

 

© 2017  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf