Red Blood Cell (RBC) Antigen Typing: E/e

CPT: 86905(x2)
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Test Details


Typing paternal RBCs for antigens that correspond to maternal antibody may aid in the prediction of hemolytic disease of the fetus and newborn. Red cell antigen typing may also be indicated for bone marrow, tissue, organ, or blood donors prior to donation. Testing a prenatal patient for red cell antigens is generally not indicated. The occurrence of the E antigen is 29% in Caucasians, 22% in Blacks, and 39% in Asians. Anti-E can cause mild hemolytic disease of the fetus and newborn. The occurrence of the e antigen is 98% in Caucasians and Blacks and 96% in Asians. Anti-e can cause rare, usually mild hemolytic disease of the fetus and newborn.


Presence of potent cold agglutinins, positive direct antiglobulin test, and (in some cases) bacteremia may interfere with test interpretation.



Specimen Requirements


Whole blood


1 mL

Minimum Volume

0.5 mL


Lavender-top (EDTA) tube

Storage Instructions

Specimens should be tested as soon as possible or within 72 hours of collection. Samples that cannot be tested immediately should be stored at 2°C to 8°C. Do not freeze red cells.

Causes for Rejection

Gross hemolysis; bacterial or other contamination

Clinical Information

Special Instructions

For Rh phenotyping, refer to test 058008.


Fung MK, Grossman JB, Hillyer CD, Westoff CM, eds. AABB Technical Manual. 18th ed. Bethesda, Md: American Association of Blood Banks;2014.
Reid ME, Lomas-Frances CG, Olsson ML, eds. Blood Group Antigen Facts Book. 3rd ed. London, England: Academic Press; 2012.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006018 E/e RBC Antigen Typing 006016 Big E 1021-5
006018 E/e RBC Antigen Typing 006017 Little e 1165-0

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