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Typing paternal RBCs for antigens that correspond to maternal antibody may aid in the prediction of hemolytic disease of the fetus and newborn. Red cell antigen typing may also be indicated for bone marrow, tissue, organ, or blood donors prior to donation. Testing a prenatal patient for red cell antigens is generally not indicated. The occurrence of the C antigen is 68% in Caucasians, 27% in Blacks, and 93% in Asians. Anti-C can cause mild hemolytic disease of the fetus and newborn. The occurrence of the c antigen is 80% in Caucasians, 98% in Blacks, and 47% in Asians. Anti-c can cause mild to severe hemolytic disease of the fetus and newborn.
Presence of potent cold agglutinins, positive direct antiglobulin test, and (in some cases) bacteremia may interfere with test interpretation.
Specimens should be tested as soon as possible or within 72 hours of collection. Samples that cannot be tested immediately should be stored at 2°C to 8°C. Do not freeze red cells.
Causes for Rejection
Gross hemolysis; bacterial or other contamination
For Rh phenotyping, refer to test 058008.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|006010||C/c RBC Antigen Typing||006008||Big C||948-0|
|006010||C/c RBC Antigen Typing||006009||Little c||1159-3|