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Group A subgroup typing of a potential organ donor for A1 may be important, as it may preclude a solid organ transplant to a group O or group B recipient. ABO antigens are expressed on the vascular endothelium of organs. Major incompatibility between donor ABO antigens and recipient plasma can result in acute humoral rejection of the transplanted organ. The occurrence of the A1 antigen is 34% in Caucasians, 19% in Blacks, and 27% in Asians. A1 is present in 80% of group A individuals.
Presence of potent cold agglutinins, a positive direct antiglobulin test, and (in some cases) bacteremia may interfere with test interpretation.
Causes for Rejection
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|006002||A1 RBC Antigen Typing||844-1||006001||A1 RBC Antigen Typing||844-1|