Prenatal Aneuploid Evaluation, Chorionic Villus Sampling, FISH

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Synonyms

  • Chromosome Analysis, Prenatal FISH, Chorionic Villus Sampling
  • CVS FISH
  • Prenatal FISH

Special Instructions

Pertinent medical findings should accompany request for FISH. It is recommended that InSight FISH testing be performed concurrently with prenatal chromosome analysis or microarray. Abnormal results should have banded chromosome confirmation.


Expected Turnaround Time

2 - 3 days


Related Documents


Specimen Requirements


Specimen

Chorionic villi


Volume

30 mg chorionic villi


Minimum Volume

5 mg chorionic villi (Note: Minimum volumes may not allow for repeat testing.)


Container

Sterile plastic conical tube


Storage Instructions

Maintain specimen at room temperature.


Causes for Rejection

No villi submitted in specimen; low volume; wrong specimen type; frozen specimen; specimen placed in fixative


Test Details


Use

Fluorescence in situ hybridization (FISH), Prenatal Chorionic Villus Sampling, FISH targeting numerical changes in 13, 18, 21, X, Y.


Limitations

Molecular mutations below the resolution of FISH will not be detected. Will not detect aneuploidy that is not targeted by FISH probes in this panel.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Fluorescence in situ hybridization (FISH)


References

Schwartz S. Efficacy and applicability of interphase fluorescence in situ hybridization for prenatal diagnosis. Am J Hum Genet. 1993 May; 52(5):851-853. 8488835
Ward BE, Gersen SL, Carelli MP, et al. Rapid prenatal diagnosis of chromosomal aneuploidies by fluorescence in situ hybridization: Clinical experience with 4500 specimens. Am J Hum Genet. 1993 May; 52(5):854-865.8488836

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510960 FISH, CVS Prenatal Aneuploid 510803 Cells Counted 64089-6
510960 FISH, CVS Prenatal Aneuploid 510804 Cells Analyzed 64086-2
510960 FISH, CVS Prenatal Aneuploid 510805 Cytogenetic Diagnosis 57318-8
510960 FISH, CVS Prenatal Aneuploid 510958 Cytogenetic Interpretation 62365-2
510960 FISH, CVS Prenatal Aneuploid 510807 Specimen Type 31208-2
510960 FISH, CVS Prenatal Aneuploid 510959 Director Review: 72486-4
510960 FISH, CVS Prenatal Aneuploid 512123 PDF 51967-8

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