Paroxysmal Nocturnal Hemoglobinuria (PNH)

CPT: Negative: 88184; 88185(x5); 88187; Positive: 88184; 88185(x7); 88187
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  • PNH

Special Instructions

Collect Monday through Thursday only. Specimens must arrive at Integrated Oncology—Brentwood or Phoenix—within 48 hours of collection.

Expected Turnaround Time

3 - 7 days

Related Documents

Specimen Requirements


Peripheral blood


4 mL

Minimum Volume

2 mL


Green-top (sodium heparin) tube (preferred) or lavender-top (EDTA)

Storage Instructions

Maintain specimen at room temperature; ship with cool pack.

Causes for Rejection

Samples with less than 1,000 WBC/ul may only have RBC analysis reported; specimens received for testing greater than 48 hours old and viability less than 80%; frozen specimen; broken container; fixed tissue; bone marrow; insufficient sample; sample greater than 48 hours old.

Test Details


The following markers are utilized to test neutrophils and/or monocytes: CD24, CD15, CD45, FLAER, CD64, CD14. If a PNH clone is identified, the following markers are used to test red blood cells: glycophorin A, CD59.


This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


Flow cytometry


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
502251 Flow Cytometry PNH 502253 Interpretation: 33664-4
502251 Flow Cytometry PNH 502254 Comment: N/A
502251 Flow Cytometry PNH 502255 Specimen: 31208-2
502251 Flow Cytometry PNH 502256 Submitted Dx: N/A
502251 Flow Cytometry PNH 502257 Viability: 33194-2
502251 Flow Cytometry PNH 502259 Cell Population N/A
502251 Flow Cytometry PNH 502260 Granulocytes: 53831-4
502251 Flow Cytometry PNH 502262 Monocytes: 60554-3
502251 Flow Cytometry PNH 502261 Red Blood Cells: 49031-8
502251 Flow Cytometry PNH 502263 Representative Histograms: N/A
502251 Flow Cytometry PNH 502264 Antibodies Performed: N/A
502251 Flow Cytometry PNH 502274 Comment: N/A
502251 Flow Cytometry PNH 503332 Director Review 72486-4

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