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Paroxysmal Nocturnal Hemoglobinuria (PNH)
Collect Monday through Thursday only. Specimens must arrive at Integrated Oncology—Brentwood or Phoenix—within 48 hours of collection.
Expected Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Green-top (sodium heparin) tube (preferred) or lavender-top (EDTA)
Maintain specimen at room temperature; ship with cool pack.
Causes for Rejection
Samples with less than 1,000 WBC/ul may only have RBC analysis reported; specimens received for testing greater than 48 hours old and viability less than 80%; frozen specimen; broken container; fixed tissue; bone marrow; insufficient sample; sample greater than 48 hours old.
The following markers are utilized to test neutrophils and/or monocytes: CD24, CD15, CD45, FLAER, CD64, CD14. If a PNH clone is identified, the following markers are used to test red blood cells: glycophorin A, CD59.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|502251||Flow Cytometry PNH||502253||Interpretation:||33664-4|
|502251||Flow Cytometry PNH||502254||Comment:||N/A|
|502251||Flow Cytometry PNH||502255||Specimen:||31208-2|
|502251||Flow Cytometry PNH||502256||Submitted Dx:||N/A|
|502251||Flow Cytometry PNH||502257||Viability:||33194-2|
|502251||Flow Cytometry PNH||502259||Cell Population||N/A|
|502251||Flow Cytometry PNH||502260||Granulocytes:||53831-4|
|502251||Flow Cytometry PNH||502262||Monocytes:||60554-3|
|502251||Flow Cytometry PNH||502261||Red Blood Cells:||49031-8|
|502251||Flow Cytometry PNH||502263||Representative Histograms:||N/A|
|502251||Flow Cytometry PNH||502264||Antibodies Performed:||N/A|
|502251||Flow Cytometry PNH||502274||Comment:||N/A|
|502251||Flow Cytometry PNH||503332||Director Review||72486-4|