Paroxysmal Nocturnal Hemoglobinuria (PNH)

CPT: Negative: 88184; 88185(x5); 88187; Positive: 88184; 88185(x7); 88187
Updated on 1/24/2018
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Test Details

Synonyms

  • PNH

Use

The following markers are utilized to test neutrophils and/or monocytes: CD24, CD15, CD45, FLAER, CD64, CD14. If a PNH clone is identified, the following markers are used to test red blood cells: glycophorin A, CD59.

Limitations

Samples with <1000 WBC/μL may only have RBC analysis reported.

Methodology

Flow cytometry

Specimen Requirements

Specimen

Peripheral blood

Volume

4 mL

5 mL

4 mL

Minimum Volume

2 mL

3 mL

2 mL

Container

Green-top (heparin) tube (preferred) or lavender-top (EDTA) tube
Green-top (sodium heparin) tube (preferred) or lavender-top (EDTA) tube
Green-top (heparin) tube (preferred) or lavender-top (EDTA) tube

Storage Instructions

Maintain specimen at room temperature; ship with cool pack.

Causes for Rejection

Specimens more than 48 hours old; specimens with viability <80%

Clinical Information

Special Instructions

Collect Monday through Thursday only. Specimens must arrive at Integrated Oncology—Brentwood or Phoenix—within 48 hours of collection.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
502251 Flow Cytometry PNH 502253 Interpretation: 33664-4
502251 Flow Cytometry PNH 502254 Comment: N/A
502251 Flow Cytometry PNH 502255 Specimen: 31208-2
502251 Flow Cytometry PNH 502256 Submitted Dx: N/A
502251 Flow Cytometry PNH 502257 Viability: 33194-2
502251 Flow Cytometry PNH 502259 Cell Population N/A
502251 Flow Cytometry PNH 502260 Granulocytes: 53831-4
502251 Flow Cytometry PNH 502262 Monocytes: 60554-3
502251 Flow Cytometry PNH 502261 Red Blood Cells: 49031-8
502251 Flow Cytometry PNH 502263 Representative Histograms: N/A
502251 Flow Cytometry PNH 502264 Antibodies Performed: N/A
502251 Flow Cytometry PNH 502274 Comment: N/A
502251 Flow Cytometry PNH 503332 Director Review 72486-4

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf