17-OH Progesterone/Creatinine Ratio, Random Urine

CPT: 82570; 83498
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Test Details

Synonyms

  • 17-OHP Urine

Use

17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism. Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Specimen Requirements

Specimen

Urine

Volume

30 mL aliquot

Minimum Volume

4 mL aliquot

Container

Use random urine transport tube containing 6N HCl or urine Monovette® with pH stabilizer (LabCorp N° 56015). Monovette® instructions accompany units. Preservative must be added to the container prior to the start of the collection. If collecting without Monovette®, use plastic urine container and adjust urine pH to <5 with 6N HCl. Caution: Strong acid. May cause skin burns.

Storage Instructions

Refrigerate.

Causes for Rejection

Specimen with no preservative; original container with pH >5

Clinical Information

Special Instructions

Random urine collection. Note: If original container is received with pH >3 but <5, adjust pH to <3 with 6N HCl.

Footnotes

1. Wong ET, Brown DR, Ulstrom RA, Steffes MW. Urinary 17 alpha-hydroxyprogesterone in diagnosis and management of congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1979 Sep; 49(3):377-380. 468971
2. Lim YJ, Yong AB, Warne GL, Montalto J. Urinary 17 alpha-hydroxyprogesterone in management of 21-hydroxylase deficiency. J Paediatr Child Health. 1995 Feb; 31(1):47-50. 7748691
3. Shibata Y. Determination of urinary 17 alpha-hydroxyprogesterone excretion using ELISA--evaluation of normal subjects and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Nihon Naibunpi Gakkai Zasshi. 1991 Aug 20; 67(8):819-839. 1813324

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070340 17-OH P/Creat Ratio, Urine 070312 17-OH Progesterone, Urine ng/dL 1670-9
070340 17-OH P/Creat Ratio, Urine 070016 Creatinine, Random U mg/dL 2161-8
070340 17-OH P/Creat Ratio, Urine 070314 17-OH P/Creat Ratio ng/mg crt 63042-6

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