17-OH Progesterone/Creatinine Ratio, Random Urine

TEST: 070340
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CPT: 82570; 83498
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Synonyms

  • 17-OHP Urine

Special Instructions

Random urine collection. Note: If original container is received with pH >3 but <5, adjust pH to <3 with 6N HCl.

Expected Turnaround Time

4 - 6 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Urine

Volume

30 mL aliquot

Minimum Volume

4 mL aliquot

Container

Use random urine transport tube containing 6N HCl or urine Monovette® with pH stabilizer (LabCorp N° 56015). Monovette® instructions accompany units. Preservative must be added to the container prior to the start of the collection. If collecting without Monovette®, use plastic urine container and adjust urine pH to <5 with 6N HCl. Caution: Strong acid. May cause skin burns.

Storage Instructions

Refrigerate.

Causes for Rejection

Specimen with no preservative; original container with pH >5

Test Details

Use

17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism. Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Footnotes

1. Wong ET, Brown DR, Ulstrom RA, Steffes MW. Urinary 17 alpha-hydroxyprogesterone in diagnosis and management of congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1979 Sep; 49(3):377-380. 468971
2. Lim YJ, Yong AB, Warne GL, Montalto J. Urinary 17 alpha-hydroxyprogesterone in management of 21-hydroxylase deficiency. J Paediatr Child Health. 1995 Feb; 31(1):47-50. 7748691
3. Shibata Y. Determination of urinary 17 alpha-hydroxyprogesterone excretion using ELISA--evaluation of normal subjects and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Nihon Naibunpi Gakkai Zasshi. 1991 Aug 20; 67(8):819-839. 1813324

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070340 17-OH P/Creat Ratio, Urine 070312 17-OH Progesterone, Urine ng/dL 1670-9
070340 17-OH P/Creat Ratio, Urine 070016 Creatinine, Random U mg/dL 2161-8
070340 17-OH P/Creat Ratio, Urine 070314 17-OH P/Creat Ratio ng/mg cr 63042-6

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