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17-OH Progesterone/Creatinine Ratio, Random Urine
- 17-OHP Urine
17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism. Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
30 mL aliquot
4 mL aliquot
Use random urine transport tube containing 6N HCl or urine Monovette® with pH stabilizer (LabCorp N° 56015). Monovette® instructions accompany units. Preservative must be added to the container prior to the start of the collection. If collecting without Monovette®, use plastic urine container and adjust urine pH to <5 with 6N HCl. Caution: Strong acid. May cause skin burns.
Causes for Rejection
Specimen with no preservative; original container with pH >5
Random urine collection. Note: If original container is received with pH >3 but <5, adjust pH to <3 with 6N HCl.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|070340||17-OH P/Creat Ratio, Urine||070312||17-OH Progesterone, Urine||ng/dL||1670-9|
|070340||17-OH P/Creat Ratio, Urine||070016||Creatinine, Random U||mg/dL||2161-8|
|070340||17-OH P/Creat Ratio, Urine||070314||17-OH P/Creat Ratio||ng/mg cr||63042-6|