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17-OH Progesterone/Creatinine Ratio, Random Urine
- 17-OHP Urine
17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism. Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
30 mL aliquot
4 mL aliquot
Use random urine transport tube containing 6N HCl or urine Monovette® with pH stabilizer (LabCorp N° 56015). Monovette® instructions accompany units. Preservative must be added to the container prior to the start of the collection. If collecting without Monovette®, use plastic urine container and adjust urine pH to <5 with 6N HCl. Caution: Strong acid. May cause skin burns.
Causes for Rejection
Specimen with no preservative; original container with pH >5
Random urine collection. Note: If original container is received with pH >3 but <5, adjust pH to <3 with 6N HCl.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|070340||17-OH P/Creat Ratio, Urine||070312||17-OH Progesterone, Urine||ng/dL||1670-9|
|070340||17-OH P/Creat Ratio, Urine||070016||Creatinine, Random U||mg/dL||2161-8|
|070340||17-OH P/Creat Ratio, Urine||070314||17-OH P/Creat Ratio||ng/mg cr||63042-6|