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17-OH Progesterone/Creatinine Ratio, 24-Hour Urine
- 17-OHP Urine
17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism.
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3
30 mL aliquot
4 mL aliquot
Instruct the patient to void at 8 AM and discard the specimen. Preservative must be added to the container prior to the start of collection. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Measure and record total urine volume on the request form. Label container with patient's name, date and time collection started, and date and time collection finished. Keep collection on ice. Remove 20 mL aliquot. pH should be ≤3.
Causes for Rejection
Specimens with no preservative; pH not ≤3.
Record total 24-hour urine volume on the test request form.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|070315||17-OH P/Creat Ratio, 24-Hr U||070016||Creatinine, Random U||mg/dL||2161-8|
|070315||17-OH P/Creat Ratio, 24-Hr U||070312||17-OH Progesterone, Urine||ng/dL||1670-9|
|070315||17-OH P/Creat Ratio, 24-Hr U||070314||17-OH P/Creat Ratio||ng/mg crt||63042-6|
|070315||17-OH P/Creat Ratio, 24-Hr U||070316||17-OH P 24 Hr, Urine||ug/24 hours||9616-4|