17-OH Progesterone/Creatinine Ratio, 24-Hour Urine

CPT: 82570; 83498
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Test Details

Synonyms

  • 17-OHP Urine

Use

17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Additional Information

Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3

Specimen Requirements

Specimen

Urine (24-hour)

Volume

30 mL aliquot

Minimum Volume

4 mL aliquot

Container

Plastic urine container with 30 mL 6N HCl preservative. Caution: Strong acid. May cause skin burns.

Collection

Instruct the patient to void at 8 AM and discard the specimen. Preservative must be added to the container prior to the start of collection. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Measure and record total urine volume on the request form. Label container with patient's name, date and time collection started, and date and time collection finished. Keep collection on ice. Remove 20 mL aliquot. pH should be ≤3.

Storage Instructions

Refrigerate

Causes for Rejection

Specimens with no preservative; pH not ≤3.

Clinical Information

Special Instructions

Record total 24-hour urine volume on the test request form.

Footnotes

1. Wong ET, Brown DR, Ulstrom RA, Steffes MW. Urinary 17 alpha-hydroxyprogesterone in diagnosis and management of congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1979 Sep; 49(3):377-380. 468971
2. Lim YJ, Yong AB, Warne GL, Montalto J. Urinary 17 alpha-hydroxyprogesterone in management of 21-hydroxylase deficiency. J Paediatr Child Health. 1995 Feb; 31(1):47-50. 7748691
3. Shibata Y. Determination of urinary 17 alpha-hydroxy-progesterone excretion using ELISA—Evaluation of normal subjects and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Nihon Naibunpi Gakkai Zasshi. 1991 Aug 20; 67(8):819-839. 1813324

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070315 17-OH P/Creat Ratio, 24-Hr U 070312 17-OH Progesterone, Urine ng/dL 1670-9
070315 17-OH P/Creat Ratio, 24-Hr U 070016 Creatinine, Random U mg/dL 2161-8
070315 17-OH P/Creat Ratio, 24-Hr U 070316 17-OH P 24 Hr, Urine ug/24 hours 9616-4
070315 17-OH P/Creat Ratio, 24-Hr U 070314 17-OH P/Creat Ratio ng/mg crt 63042-6

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