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NRAS is a guanosine triphosphate (GTP)-binding protein involved in downstream receptor signaling, which is critical for cell proliferation, survival, and differentiation. Mutations in the NRAS oncogene are frequently found in human cancers. They are common in melanomas, colorectal cancer, and thyroid cancer. This assay detects NRAS mutations in exons 2, 3, and 4, allowing the determination of drug response.
This assay is able to detect 5% mutation in a background of wild-type DNA. This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
SNaPshot Multiplex PCR (primer extension-based method)
Formalin-fixed, paraffin-embedded (FFPE) tissue or slides.
Formalin-fixed, paraffin-embedded tissue block or four unstained slides and one matching H&E-stained slide at 5 μM.
Two unstained slides and one matching H&E-stained slide at 5 μM. Samples with >4mm² and ≥50% tumor content are preferred.
Formalin-fixed, paraffin-embedded (FFPE) tissue blocks or slides
Maintain blocks/slides at room temperature.
Causes for Rejection
Tumor block containing insufficient tumor tissue; broken or stained slides
Provide a copy of the pathology report; the NRAS test will be delayed if the pathology report is not received. Direct any questions regarding this test to customer service at 800-345-4363.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|481120||NRAS Extended Analysis||481121||Results:||21719-0|
|481120||NRAS Extended Analysis||481122||Indications:||42349-1|
|481120||NRAS Extended Analysis||481123||Specimen Location:||N/A|
|481120||NRAS Extended Analysis||481124||Specimen Type:||31208-2|
|481120||NRAS Extended Analysis||481125||Block Number:||57723-9|
|481120||NRAS Extended Analysis||481088||Nucleotide Change:||48004-6|
|481120||NRAS Extended Analysis||481089||Amino Acid Change:||48005-3|
|481120||NRAS Extended Analysis||481126||Background:||8251-1|
|481120||NRAS Extended Analysis||481127||Methodology:||49549-9|
|481120||NRAS Extended Analysis||481128||References:||75608-0|
|481120||NRAS Extended Analysis||481131||Director Review:||72486-4|
|481120||NRAS Extended Analysis||480903||Microdissection Performed||8100-0|
|481120||NRAS Extended Analysis||481146||Referring Physician||18781-5|
|481120||NRAS Extended Analysis||481147||Treating Physician||18781-5|
|481120||NRAS Extended Analysis||481148||Body Site||39111-0|
|481120||NRAS Extended Analysis||481149||Client Specimen ID||N/A|
|481120||NRAS Extended Analysis||481150||Specimens Received||31208-2|
|481120||NRAS Extended Analysis||481151||Clinical Data||55752-0|
|481120||NRAS Extended Analysis||481153||Interpretation||62365-2|
|481120||NRAS Extended Analysis||481154||Analytical Results||21719-0|
|481120||NRAS Extended Analysis||481155||Comments||77202-0|
|481120||NRAS Extended Analysis||481157||Signed By||19139-5|
|481120||NRAS Extended Analysis||481158||Disclaimers||N/A|
|481120||NRAS Extended Analysis||481159||51969-4|