Find Locations
For hours, walk-ins and appointments.Special Instructions
If you have questions, please telephone HLA customer service at 800-533-1037 for assistance in selecting the appropriate HLA test for the patient.
Expected Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Whole blood or buccal swabs
Volume
7 mL or four buccal swabs
Minimum Volume
3 mL or four buccal swabs
Container
Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). If submitting buccal swabs, please use the kit provided by LabCorp. To obtain the buccal swab kit or to discuss other specimen types, please telephone 800-533-1037.
Storage Instructions
Maintain specimen at room temperature. Protect from extreme heat or cold.
Causes for Rejection
Incorrect specimen container (tube type); yellow-top (ACD) tube
Test Details
Use
HLA DQB1*06:02 and HLA DQA1*01:02 are associated statistically with narcolepsy and are sometimes used as tests in support of that diagnosis.
Limitations
Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, fresh specimens should be collected for retesting. Narcolepsy-associated HLA alleles are not diagnostic, but they are useful in stratifying risk.
Methodology
Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (Luminex®)
References
Mignot E, Lin L, Rogers W, et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet. 2000 Mar; 68(3):686-699.11179016
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 167139 | Narcolepsy Evaluation | 167140 | DQA1*01:02 | 53737-3 | ||
| 167139 | Narcolepsy Evaluation | 167141 | DQB1*06:02 | 63558-1 | ||
| 167139 | Narcolepsy Evaluation | 167085 | Comment: | 49549-9 | ||
| 167139 | Narcolepsy Evaluation | 167086 | QC | N/A | ||
| 167139 | Narcolepsy Evaluation | 167149 | Please Note: | 77202-0 |
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