Narcolepsy Evaluation

CPT: 81383(x2)
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Test Details

Use

HLA DQB1*06:02 and HLA DQA1*01:02 are associated statistically with narcolepsy and are sometimes used as tests in support of that diagnosis.

Limitations

Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, fresh specimens should be collected for retesting. Narcolepsy-associated HLA alleles are not diagnostic, but they are useful in stratifying risk.

Methodology

Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (Luminex®)

Specimen Requirements

Specimen

Whole blood or buccal swabs

Volume

7 mL or four buccal swabs

Minimum Volume

3 mL or four buccal swabs

Container

Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). If submitting buccal swabs, please use the kit provided by LabCorp. To obtain the buccal swab kit or to discuss other specimen types, please telephone 800-533-1037.

Storage Instructions

Maintain specimen at room temperature. Protect from extreme heat or cold.

Causes for Rejection

Incorrect specimen container (tube type); yellow-top (ACD) tube

Clinical Information

Special Instructions

If you have questions, please telephone HLA customer service at 800-533-1037 for assistance in selecting the appropriate HLA test for the patient.

References

Mignot E, Lin L, Rogers W, et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet. 2000 Mar; 68(3):686-699.11179016

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
167139 Narcolepsy Evaluation 167140 DQA1*01:02 53737-3
167139 Narcolepsy Evaluation 167141 DQB1*06:02 63558-1
167139 Narcolepsy Evaluation 167085 Comment: 49549-9
167139 Narcolepsy Evaluation 167086 QC N/A
167139 Narcolepsy Evaluation 167149 Please Note: N/A

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf