Multiple Myeloma Enrichment SNP Microarray−Oncology (Reveal®)

CPT: 81277
Updated on 02/29/2024
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Test Includes

DNA extraction; interpretation


Special Instructions

Please provide the patient's clinical history and ancillary oncology testing. Contact customer service with any questions at 800-345-4363.


Expected Turnaround Time

11 - 15 days


Specimen Requirements


Specimen

Bone marrow


Volume

2 mL bone marrow


Minimum Volume

1 mL bone marrow for array only (Note: This volume does not allow for repeat testing.)


Container

Green-top (heparin) tube (preferred), lavender-top (EDTA) tube, sterile container containing sterile saline, Ringer's lactate or Hanks' balanced salt solution, or transport medium provided by the cytogenetic laboratory.


Storage Instructions

Maintain specimen at room temperature.


Stability Requirements

Temperature

Period

Room temperature

5 days


Causes for Rejection

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets; whole blood

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets; whole blood

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets; whole blood

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets; whole blood

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets; whole blood


Test Details


Use

This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.


Limitations

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses more than 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.

SNP Microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.

SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses more than 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.


References

Gunnarsson R, Staaf J, Jansson M, et al. Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia−A comparative study of four differently designed, high resolution microarray platforms. Genes Chromosomes Cancer. 2008 Aug; 47(8):697-711.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510195 MM Enrich CMA 510188 Specimen Type 31208-2
510195 MM Enrich CMA 510189 # of Genotyping Targets N/A
510195 MM Enrich CMA 510190 Diagnosis 62357-9
510195 MM Enrich CMA 510191 Interpretation 62365-2
510195 MM Enrich CMA 510192 Director Review: 48672-0
510195 MM Enrich CMA 512123 PDF 51967-8

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