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For hours, walk-ins and appointments.Multiple Myeloma Enriched Microarray and Multiple Myeloma FISH
CPT:
81277
Synonyms
- Monoclonal Gammopathy of Undetermined Significance (MGUS)
- Oncology Array
- Plasma Cell Leukemia
- Reveal® MM Enrich CMA
Test Includes
Fluorescence in situ hybridization (FISH) for multiple myeloma (MM); IgH-CCDN1; FGFR3/IgH; CMAF/IgH; SNP microarray (Reveal®)
Special Instructions
Indicate pertinent clinical diagnosis and previous cytogenetics studies on the test request form.
Expected Turnaround Time
10 - 14 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Specimen Requirements
Specimen
Bone marrow
Volume
1 to 3 mL bone marrow
Minimum Volume
1 mL bone marrow
Container
Green-top (sodium heparin) tube with bone marrow aspirate.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Whole blood; broken tube. For SNP microarray, quantity not sufficient for analysis, gel-separator tubes, microtainer tubes, fixed cell pellets.
Test Details
Use
Diagnostic test for multiple myeloma. Plasma cell enrichment diagnosis increased as much as 50% to 100%. The FISH results on the enriched assay should not be used as a quantitative assay, since the abnormal cells do not represent the percentage of abnormal cells in the aspirate. The SNP assay will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.
Limitations
The SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Fluorescence in situ hybridization (FISH) and plasma cell enrichment. SNP microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.
References
Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: A workshop report. Cancer Res. 2004 Feb 15;64:1546-1558.14989251
Fonseca R, Bergsagel PL, Drach J, et al. International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review. Leukemia. 2009 Dec;23(12):2210-2221.19798094
Pozdnyakova O, Crowley-Larsen P, Zota V, Wang SA, Miron PM. Interphase FISH in plasma cell dyscrasia: Increased in abnormality detection with plasma cell enrichment. Cancer Genet Cytogenet. 2009 Mar;189(2):112-117.19215792
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 510904 | MM Enrich CMA + MM Trans FISH | 511435 | Specimen Type | 31208-2 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510189 | # of Genotyping Targets | N/A | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510190 | Diagnosis | 62357-9 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510191 | Interpretation | 62365-2 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510192 | Director Review: | 48672-0 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 512123 | 51967-8 | |||
| 510904 | MM Enrich CMA + MM Trans FISH | 510816 | Specimen Type | 31208-2 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510817 | Cells Counted | 62361-1 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510818 | Cells Analyzed | 62360-3 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510819 | FISH Result | 62357-9 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510964 | Interpretation | 62365-2 | ||
| 510904 | MM Enrich CMA + MM Trans FISH | 510973 | Director Review: | 48672-0 |
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