Maternal Cell Contamination

CPT: 81265
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Test Details

Use

Quality assurance for interpretation of prenatal molecular genetic test results

Limitations

This test is not applicable in nonmaternity contexts.

Results of this test are for investigational purposes only. The performance characteristics of this assay have been determined by LabCorp. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

Analysis of short tandem repeat markers by polymerase chain reaction (PCR) and capillary electrophoresis

Specimen Requirements

Specimen

Whole blood or LabCorp buccal swab kit (Buccal swab collection kit contains instructions for use of a buccal swab.), amniotic fluid, or chorionic villus sample (CVS) (Submission of maternal blood is required for fetal testing.)

Volume

7 mL whole blood or LabCorp buccal swab kit, 10 mL amniotic fluid, or 20 mg CVS

Minimum Volume

3 mL whole blood or two buccal swabs, 5 mL amniotic fluid, or 10 mg CVS

Container

Lavender-top (EDTA) tube or yellow-top (ACD) tube or LabCorp buccal swab kit, sterile plastic conical tube, or two confluent T-25 flasks for fetal testing

Storage Instructions

Maintain specimen at room temperature or refrigerate.

Causes for Rejection

Frozen or hemolyzed specimen; quantity not sufficient for analysis; improper container

Clinical Information

Special Instructions

If a prenatal specimen (CVS or amniotic fluid) has not already been submitted to LabCorp for other testing, it must now be provided to complete maternal cell contamination (MCC) analysis. LabCorp buccal swab kits can be ordered using PeopleSoft N° 3177.

References

Shadravan F. Sizing precision and reproducibility studies of AmpFLP-STR® kits with ABI Prism® 3100 genetic analyzer. Proc Am Acad Forensic Sci. 2001; 7:26.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511402 Maternal Cell Contamination 511401 Maternal Cell Contamination 59266-7
511402 Maternal Cell Contamination 511404 Method/Limitations 49549-9
511402 Maternal Cell Contamination 511887 Specimen Type 31208-2
511402 Maternal Cell Contamination 511888 Result 41103-3
511402 Maternal Cell Contamination 511889 Director Review 72486-4

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf