Lyme Disease, Borrelia burgdorferi C6 Antigen With Reflex to Western Blot

CPT: 86618. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Details

Synonyms

  • C6 Antigen (Borrelia burgdorferi)

Test Includes

Reflex to Western blot

Use

Aid in the diagnosis of acute and later stages of infections by Borrelia burgdorferi, the spirochete associated with Lyme disease. Lyme disease is a common vector-borne disease in the US caused by B burgdorferi, which is transmitted through the bite of infected ticks (Ixodes spp). C6 is the antigen derived from the VIsE protein, which has been shown to be both specific and highly immunogenic. Cross-reactivity in individuals vaccinated with the licensed recombinant OspA Lyme disease (Lymerix®) is not observed.1

Methodology

Enzyme-linked immunosorbent assay (ELISA); reflex to Western blot if equivocal or positive

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Gel barrier tube or red-top tube

Storage Instructions

Refrigerate. Specimen is stable for ten days refrigerated. For storage longer than 10 days, freeze the specimen.

Causes for Rejection

Hemolyzed or lipemic sera; microbial contamination; plasma submitted

Clinical Information

Footnotes

1. Marques AR, Martin DS, Philipp MT. Evaluation of the C6 peptide enzyme-linked immunosorbent assay for individuals vaccinated with the recombinant OspA vaccine. J Clin Microbiol. 2002 Jul; 40(7):2591-2593. 12089281

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
015400 C6 B. burgdorferi (Lyme) 38173-1 015401 C6 Borrelia burgdorferi (Lyme) index 38173-1
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163635 IgG P93 Ab. 9597-6
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163605 IgG P66 Ab. 9596-8
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163623 IgG P58 Ab. 9595-0
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163641 IgG P45 Ab. 9594-3
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163607 IgG P41 Ab. 9593-5
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163598 IgG P39 Ab. 9592-7
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163633 IgG P30 Ab. 9591-9
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163636 IgG P28 Ab. 9590-1
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163642 IgG P23 Ab. 9589-3
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163627 IgG P18 Ab. 9588-5
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163640 Lyme IgG WB Interp. 13502-0
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163616 IgM P41 Ab. 9587-7
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163599 IgM P39 Ab. 9599-2
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163638 IgM P23 Ab. 9598-4
Reflex Table for C6 Borrelia burgdorferi (Lyme)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163600 Lyme, Western Blot, Serum 163639 Lyme IgM WB Interp. 13503-8

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf