Leukemia/Lymphoma Monitor Profile

CPT: 82232; 84275
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Test Details

Test Includes

β2 microglobulin, serial monitor report; lipid-associated sialic acid (LASA), serial monitor report

Use

β2-microglobulin is increased nonspecifically in active chronic lymphocytic leukemia (CLL) due to increased lymphocyte turnover.

Limitations

This profile is not useful as a screening or diagnostic test for leukemia or lymphoma.

The LASA test may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

Methodology

See individual tests.

Additional Information

β2-microglobulin is a cell membrane associated 100 amino acid peptide, a component of the lymphocyte HLA complex. It is increased nonspecifically in inflammatory reactions and in active chronic lymphocytic leukemia in which there is increased lymphocyte turnover.

Specimen Requirements

Specimen

Serum

Volume

2 mL

Minimum Volume

1 mL

Container

Red-top tube or gel-barrier tube

Collection

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Storage Instructions

Refrigerate

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; whole blood specimen

Clinical Information

Special Instructions

The account must submit the patient's Social Security number to monitor.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
485029 Leukemia/Lymphoma Monitor Prof 010181 Beta-2 Microglobulin, Serum mg/L 1952-1
485029 Leukemia/Lymphoma Monitor Prof 480133 Lipid-Associated Sialic Acid mg/dL 2943-9

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf