Legionella pneumophila Antibody

TEST: 164616
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CPT: 86713
Updated on 03/17/2024
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Special Instructions

This assay differentiates between previous exposure/infection and current infection. Serological testing is not recommended for diagnosis. Per current recommendations, culture of lower respiratory secretions and/or the Legionella urinary test should be used for diagnosis of infection with Legionella.

Send paired serum samples, one during the acute stage, and the second, three to six weeks later, during the convalescent stage.

This assay differentiates between previous exposure/infection and current infection. Serological testing is not recommended for diagnosis. Per current recommendations, culture of lower respiratory secretions and/or the Legionella urinary test should be used for diagnosis of infection with Legionella.

Expected Turnaround Time

1 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum

Volume

0.4 mL

Minimum Volume

0.2 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Maintain specimen at room temperature.

Room temperature

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

7 days

Frozen

7 days

Freeze/thaw cycles

Stable x3

Temperature

Period

Room temperature

7 days

Refrigerated

7 days

Frozen

7 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Test Details

Use

This assay can be used to identify exposure to Legionella pneumophila but serological testing is not recommended for diagnosis of Legionella infection. This assay does not differentiate between previous exposure/infection and current infection. Per current recommendations, culture of lower respiratory secretions and/or the Legionella urinary antigen test should be used for diagnosis of infection with Legionella.

This assay can be used to identify exposure to Legionella pneumophila but serological testing is not recommended for diagnosis of Legionella infection. This assay does not differentiate between previous exposure/infection and current infection. Per current recommendations, culture of lower respiratory secretions and/or the Legionella urinary antigen test should be used for diagnosis of infection with Legionella.

Limitations

This assay detects antibodies against L. pneumophila serogroups 1 through 6. It does not detect non-pneumophila, or atypical, Legionella species. This assay cannot differentiate between previous exposure/infection and current infection. A diagnosis should be made on the basis of Legionella serology results alone; test results should be interpreted in conjunction with clinical evaluation and other diagnostic procedures.

This system tests for L pneumophila serogroups 1 through 6. It does not test for nonpneumophila, or atypical, Legionella species. A diagnosis should not be made on the basis of anti-Legionella serology results alone; test results should be interpreted in conjunction with the clinical evaluation and other diagnostic procedures.

This assay detects antibodies against L. pneumophila serogroups 1 through 6. It does not detect non-pneumophila, or atypical, Legionella species. This assay cannot differentiate between previous exposure/infection and current infection. A diagnosis should be made on the basis of Legionella serology results alone; test results should be interpreted in conjunction with clinical evaluation and other diagnostic procedures.

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Reference Interval

Non-reactive

The positive cutoff has been set to the equivalent for an IFA titer of 1:256. If only one specimen is submitted, a positive is presumptive supporting evidence of exposure.

Non-reactive

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164616 Legionella pneumophila Abs. 30046-7 164618 Legionella pneumophila Abs. 30046-7

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf