Isocyanates Profile

CPT: 86003(x3)
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Test Details

Test Includes

Hexamethylene diisocyanate (HDI)-specific IgE; methylene diphenyl diisocyanate (MDI)-specific IgE; toluene diisocyanate (TDI)-specific IgE

Methodology

Thermo Fisher ImmunoCAP®

Reference Interval

Normal: 0.00−2.00/HSA (human serum albumin)

Additional Information

Diagnostic information: Exposure to isocyanates may cause chemical bronchitis with initial symptoms of throat irritation, laryngitis, coughing, and chest pain or tightness.1 Asthma (with symptoms of wheezing, coughing, and shortness of breath) may also follow exposure to isocyanates.1 Other effects associated with isocyanate exposure are hypersensitive pneumonitis, chronic pulmonary disease, and contact dermatitis (following direct skin contact).1

Clinical significance: Between 2% and 15% of all asthma associated with industry attributed to occupational exposure to chemicals.2 Quantitative allergen-specific IgE testing offers the capability of monitoring workplace exposure to isocyanates through the measurement of acid isocyanate-specific IgE levels. Increases in acid specific IgE levels are correlated with elevations in exposure.1

Sources of exposure: TDI, MDI, and HDI are three of the most frequently used isocyanates in industry.3 The isocyanates are used primarily as starting materials for a variety of manufacturing processes, including the production of plastics, polyurethane, foams, and electrical wire insulation.1 Isocyanates are also common components of paints and other durable and protective finishes, adhesives, and elastomers in automobile bumpers, printing rolls, and coated fabrics.1 Exposure can occur at any stage from the initial manufacturer of the isocyanates to their final use in various production processes.1 Exposure can also occur from the application of paints and polyurethanes, from the handling and machining of foams, and from the combustion of these materials.1

Specimen Requirements

Specimen

Serum

Volume

1 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Clinical Information

Footnotes

1. Phillips KK, Peters JM. Isocyanates. In: Sullivan JB, Krieger GR, eds. Hazardous Materials Toxicology, Clinical Principles of Environmental Health. Baltimore, Md: Williams & Wilkins;1992:946-949.
2. Brooks BO, Sullivan JB. Immunotoxicology. In: Sullivan JB, Krieger GR, eds.Hazardous Material Toxicology: Clinical Principles of Environmental Health. Baltimore, Md: Williams & Wilkins;1992:209-210.
3. Montanaro A. Isocyanate asthma. In: Bardana EJ, Montanaro A, O'Hollaren MT, eds. Occupational Asthma. Philadelphia, Pa: Hanley & Belfus Inc;1992:145-147.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
630988 Isocyanates Profile 602662 K075-IgE Isocyanate TDI kU/L 7431-0
630988 Isocyanates Profile 602663 K076-IgE Isocyanate MDI kU/L 7430-2
630988 Isocyanates Profile 602665 K077-IgE Isocyanate HDI kU/L 7429-4

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