Iodine, Serum or Plasma

CPT: 83789
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Test Details


Monitor exposure to iodine; evaluate for iodine deficiency disorders (IDDs), excessive iodine intake, or iodine in the workplace

IDDS by Age Group

Age Groups

Health Consequences of Iodine Deficiency

Zimmerman MB. Iodine deficiency. Endocrine Reviews. The Endocrine Society. 2009; 30:376-408.

All ages


Increased susceptibility of thyroid gland to nuclear radiation




Congenital anomalies

Perinatal mortality


Infant mortality

Endemic cretinism

Children and adolescents

Impaired mental function

Delayed physical development


Impaired mental function

Reduced work productivity

Toxic nodular goiter; iodine-induced hyperthyroidism

Increased occurrence of hypothyroidism in moderate-to-severe iodine deficiency; decreased occurrence of hypothyroidism in mild-to-moderate iodine deficiency

Other forms of thyroid problems, namely iodine-induced hypothyroidism, autoimmune thyroiditis, and hyperthyroidism associated with excessive iodine intake have become a greater concern than deficiency disorders.1


Inductively coupled plasma/mass spectrometry (ICP/MS)

Reference Interval

40.0−92.0 μg/L

Specimen Requirements


Serum or plasma


0.5 mL

Minimum Volume

0.4 mL


Royal blue-top (EDTA) tube or royal blue-top tube without EDTA


Submit original unopened tube or serum or plasma removed from a royal blue-top tube, and transfer to a certified metal-free plastic transport tube (PeopleSoft N° 111166) for shipment to the laboratory.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Certified metal-free plastic transport tube not submitted

Clinical Information


1. Hollowell JG, Staehling NW, Hannon WH, et al. Iodine nutrition in the United States, trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-1974 and 1988-1994). J Clin Endocrinol Metab. 1998; 83(10):3401-3408.9768638


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070034 Iodine, Serum or Plasma 2494-3 070035 Iodine, Serum or Plasma ug/L 2494-3

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