Interleukin-2, Plasma

CPT: 83520
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Test Details

Synonyms

  • IL-2
  • IL2

Use

Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes.1 IL-2 plays a role in promoting the clonal expansion of antigen-specific cytotoxic and suppressor T cells. In vitro studies suggest that IL-2 may also be produced by dendritic cells and certain lymphoma cell lines.1 In addition, IL-2 has been shown to mediate multiple immune responses on a variety of cell types. IL-2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation, and cytocidal activity of monocytes; induces the growth of natural killer cells and stimulates cytokine production by these cells, as well as enhancing the cytolytic activity of these cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes.1

Limitations

Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Specimen Requirements

Specimen

Plasma

Volume

0.5 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)

Container

Lavender-top (EDTA) tube

Collection

Separate plasma from cells. Transfer plasma to a plastic transport tube.

Storage Instructions

Refrigerate; stable for 14 days. Stable at room temperature or frozen for 14 days. Freeze/thaw cycles x3.

Causes for Rejection

Gross hemolysis; sample left on cells

Clinical Information

Footnotes

1. Lin J-X, Leonard WJ. Interleukin-2. In: Thomson AW, Lotze MT, eds. Cytokine Handbook. 4th ed, vol 1. London, UK and San Diego, Calif: Academic Press, Elsevier Science; 2003:167-199.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
140812 Interleukin-2, Plasma 33939-0 140813 Interleukin-2, Plasma pg/mL 33939-0

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