Integrated 1

CPT: 84163
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Test Details


  • Down Syndrome
  • Nuchal Translucency (NT)
  • PAPP-A


Screening test for open neural tube defects, Down syndrome, and trisomy 18


Integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.


Chemiluminescent immunoassay

Specimen Requirements




3 mL

Minimum Volume

1 mL


Gel-barrier tube, no thrombin additive


Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

7 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

Clinical Information

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. Client must provide fetal nuchal translucency (NT) measurement and crown rump length measurement. The NT measurement must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided. The following information also must be provided: patient's race, patient's weight, patient's date of birth, patient's insulin-dependent diabetic status, and the number of fetuses. Also indicate patient history (ie, prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Serum testing is provided from 10.0 to 13.9 weeks of gestation. NT can be assessed when the CRL is 45 to 84 mm.


Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med. 1999 Aug 12; 341(7):461-467.10441601


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
017100 Integrated 1 017101 Test Results: 49586-1
017100 Integrated 1 017102 Submit Part 2 Sample Using N/A
017100 Integrated 1 017103 Crown Rump Length mm 11957-8
017100 Integrated 1 017140 CRL Scan 34970-4
017100 Integrated 1 017148 Gest. Age on Collection Date weeks 18185-9
017100 Integrated 1 017149 Maternal Age at EDD years 43993-5
017100 Integrated 1 017150 Race 21484-1
017100 Integrated 1 017155 Weight lbs 29463-7
017100 Integrated 1 017156 Number of Fetuses 11878-6
017100 Integrated 1 017157 Nuchal Translucency (NT) mm 12146-7
017100 Integrated 1 017159 Comments: 77202-0
017100 Integrated 1 017866 Results N/A
017100 Integrated 1 018019 Sonographer ID# 49089-6
017100 Integrated 1 018060 NT Twin B mm 12146-7
017100 Integrated 1 018061 Crown Rump Length Twin B mm 11957-8
017100 Integrated 1 018062 CRL Scan Twin B 34970-4
017100 Integrated 1 018172 Additional US N/A
017100 Integrated 1 018219 PAPP-A Value ng/mL 48407-1
017100 Integrated 1 018286 Note: N/A
017100 Integrated 1 511933 PDF 11502-2

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