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Immunoglobulin E, Total
Evaluate immunoglobulin status in possible atopic disease
Normal IgE levels do not exclude allergic phenomena.
Thermo Fisher ImmunoCAP®
• <1 year: 0−15 IU/mL
• 1 to 5 years: 0−60 IU/mL
• 6 to 9 years: 0−90 IU/mL
• 10 to 15 years: 0−200 IU/mL
• Adults: 0−100 IU/mL
The concentration of IgE in serum of normal individuals typically represents <0.001% of the total immunoglobulins present.1,2 Immunoglobulins of the IgE class play an important role in mediating the atopic reactions that occur when sensitive individuals are exposed to allergens. IgE has a structure that is similar to other immunoglobulins in that it consists of four chains: two light chains and two heavy chains.1 The heavy chains for each IgE molecule contain a variable region that accounts for antigen specificity. Since IgE myeloma is extremely rare, the clinical utility of measuring IgE levels generally involves its role as the mediator of the allergic response. The majority of IgE molecules in serum are bound to the surface of mast cells and basophilic granulocytes. The interaction of allergens with the cell-bound allergen-specific IgE causes these cells to release histamines and other vasoactive substances, thereby initiating the allergic reaction. Approximately 50% of individuals with allergic rhinitis or asthma will have elevated levels of IgE;1 however, a large number of individuals with allergy and elevated levels of IgE to specific allergens will have normal levels of total IgE. Studies have indicated that total IgE levels are often elevated in patients with atopic dermatitis and the concentration of IgE tends to correlate with severity of eczema.1 Total IgE levels can also be elevated in patients with parasitic infections, allergic bronchopulmonary aspergillosis, or immunodeficiency.1,2
0.3 mL (Note: This volume does not allow for repeat testing.)
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Causes for Rejection
Improper labeling; excessive hemolysis
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|002170||Immunoglobulin E, Total||19113-0||002173||Immunoglobulin E, Total||IU/mL||19113-0|