Immunofixation (IFE) and Protein Electrophoresis, Cerebrospinal Fluid

CPT: 84157; 84166; 86335
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Test Details


  • CSF Immunoelectrophoresis
  • CSF Immunofixation
  • Globulins, CSF
  • IFE/Protein Electrophoresis, CSF

Test Includes

Immunofixation of CSF; CSF protein electrophoresis


Evaluate possible multiple sclerosis, subacute sclerosing panencephalitis, and other chronic CNS disorders associated with local IgG synthesis


Agarose gel immunofixation (IFE); protein electrophoresis on agarose media

Reference Interval

Normal pattern

Specimen Requirements


Cerebrospinal fluid (CSF)


5 mL

Minimum Volume

2 mL


Sterile container

Storage Instructions


Causes for Rejection

Bloody CSF; less than 2 mL CSF

Clinical Information

Special Instructions

The request form should include patient's age and clinical diagnosis.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
001438 IFE and PE, CSF 002055 Protein, Total, CSF mg/dL 2880-3
001438 IFE and PE, CSF 122370 PDF 11502-2
001438 IFE and PE, CSF 143800 IFE, CSF 13174-8
001438 IFE and PE, CSF 143826 Pre-Albumin (CSF) % 13973-3
001438 IFE and PE, CSF 143834 Albumin (CSF) % 13974-1
001438 IFE and PE, CSF 143842 Alpha-1-Globulin (CSF) % 13972-5
001438 IFE and PE, CSF 143859 Alpha-2-Globulin (CSF) % 13975-8
001438 IFE and PE, CSF 143867 Beta Globulin (CSF) % 13976-6
001438 IFE and PE, CSF 143876 Gamma Globulin (CSF) % 13977-4

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