IgG Index and Synthesis Rate

CPT: 82040; 82042; 82784(x2)
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Test Details

Limitations

Conditions in which lymphoreticular elements of the CNS produce immunoglobulins will result in false-positive (in relation to multiple sclerosis) elevations. Such conditions include (but are not limited to) aseptic meningitis, lymphoma, neurosyphilis, Guillain-Barré syndrome, and cerebral lupus erythematosus. These conditions, however, are either uncommon or are not frequently associated with an increased IgG index.

Methodology

CSF IgG, CSF albumin and serum IgG: Immunologic; serum albumin: spectrophotometry; ratio, index and synthesis rate by calculation

Specimen Requirements

Specimen

Serum and cerebrospinal fluid (CSF)

Volume

1.5 mL serum and 1 mL CSF

Minimum Volume

0.7 mL serum and 0.5 mL CSF

Container

Red-top tube or gel-barrier tube and sterile container for CSF

Storage Instructions

Room temperature. CSF: Stable at room temperature, refrigerated, or frozen for 14 days; freeze/thaw cycles: stable x2. Serum: Stable at room temperature, refrigerated, or frozen for 14 days; freeze/thaw cycles: stable x3.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
203836 IgG Index+Synthesis Rate 012212 IgG, Quant, CSF mg/dL 2464-6
203836 IgG Index+Synthesis Rate 012230 Albumin, CSF mg/dL 1746-7
203836 IgG Index+Synthesis Rate 001776 Immunoglobulin G, Qn, Serum mg/dL 2465-3
203836 IgG Index+Synthesis Rate 001081 Albumin, Serum g/dL 1751-7
203836 IgG Index+Synthesis Rate 160311 IgG/Alb Ratio, CSF 2470-3
203836 IgG Index+Synthesis Rate 101124 CSF IgG Index 14117-6
203836 IgG Index+Synthesis Rate 085937 IgG, Syn Rate,CSF mg/day 14116-8
203836 IgG Index+Synthesis Rate 120173 CSF/Serum Alb. Index 1756-6

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf