Human Immunodeficiency Virus 1 (HIV-1) Trofile® DNA (Monogram® Coreceptor Tropism), Whole Blood

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Expected Turnaround Time

16 - 22 days



Specimen Requirements


Specimen

Whole blood, frozen


Volume

4 mL


Container

Lavender-top (EDTA) tube


Collection

Collect specimen in lavender-top (EDTA) tube. Do not centrifuge. Ship frozen. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Freeze.


Causes for Rejection

Insufficient volume; heparinized plasma; nonfrozen specimen


Test Details


Use

Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as Selzentry™ (maraviroc).


Limitations

This procedure should be used for patients with documented HIV-1 infection and undetectable viral loads.


Methodology

Polymerase chain reaction (PCR) amplification and viral culture. Trofile™ is a registered trademark of Monogram Biosciences.


References

Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother. 2007 Feb; 51(2):566-575. 17116663

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
829670 Trofile(R) DNA 550341 Trofile(R) DNA PDF 51969-4
829670 Trofile(R) DNA 550347 Tropotype: 80690-1
829670 Trofile(R) DNA 829671 Trofile(R) DNA 50790-5
829670 Trofile(R) DNA 829672 Trofile(R) DNA Interpretation 62364-5

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