Human Immunodeficiency Virus 1 (HIV-1) Trofile® DNA (Monogram® Coreceptor Tropism), Whole Blood

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Expected Turnaround Time

16 - 22 days

Specimen Requirements


Whole blood, frozen


4 mL


Lavender-top (EDTA) tube


Collect specimen in lavender-top (EDTA) tube. Do not centrifuge. Ship frozen. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Causes for Rejection

Insufficient volume; heparinized plasma; nonfrozen specimen

Test Details


Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as Selzentry™ (maraviroc).


This procedure should be used for patients with documented HIV-1 infection and undetectable viral loads.


Polymerase chain reaction (PCR) amplification and viral culture. Trofile™ is a registered trademark of Monogram Biosciences.


Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother. 2007 Feb; 51(2):566-575. 17116663


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
829670 Trofile(R) DNA 550341 Trofile(R) DNA PDF 51969-4
829670 Trofile(R) DNA 550347 Tropotype: 80690-1
829670 Trofile(R) DNA 829671 Trofile(R) DNA 50790-5
829670 Trofile(R) DNA 829672 Trofile(R) DNA Interpretation 62364-5

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