HLA Class II Antibody, Panel-reactive Antibody (PRA)

CPT: 86831
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Synonyms

  • HLA Antibody, PRA
  • HLA Class 1 Antibody
  • White Cell Antibody

Special Instructions

Collect specimen prior to dialysis. Do not collect if patient has received antithymocyte globulin, OKT3, or alemtuzumab (Campath®) recently. These drugs may cause false-positive results.


Expected Turnaround Time

3 - 5 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

7 mL


Minimum Volume

3 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Maintain specimen at room temperature. Protect from extreme heat or cold. Serum may be frozen.


Stability Requirements

Temperature

Period

Room temperature

2 days

Refrigerated

1 month

Frozen

2 years


Causes for Rejection

Highly lipemic or hemolyzed specimen


Test Details


Use

Solid organ transplantation


Limitations

Detects antibodies of the IgG isotype and not IgM antibodies, which are usually indicative of autoantibodies.


Methodology

Solid phase (Luminex)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
168056 HLA Class II Antibody ID 167119 HLA Ab ID 2 % CPRA 46995-7
168056 HLA Class II Antibody ID 167106 Comment: 49549-9

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