HLA A High Resolution

CPT: 81380
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Test Details

Use

High resolution HLA typing is preferred for matching of bone marrow transplant donors and recipients. Other clinical indications may require high resolution typing to rule out alternative allele combinations.

High resolution Typing for HLA Class I will meet the following criteria: All ambiguities within exons 2 and 3 (which defines the antigen recognition site) and exon 4, will be resolved. Those ambiguities that remain will be reported as an allele code.

Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Methodology

Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.

Specimen Requirements

Specimen

Whole blood

Volume

7 mL

Minimum Volume

3 mL

Container

Lavender-top (EDTA) tube

Storage Instructions

Maintain specimen at room temperature; protect from extreme heat or cold. Do not freeze.

Causes for Rejection

Hemolyzed specimen; clotted specimen; wrong specimen container

Clinical Information

Special Instructions

If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
167377 HLA-A (HR) 019414 HLA-A 13298-5
167377 HLA-A (HR) 019415 HLA-A 13298-5
167377 HLA-A (HR) 167384 HLA Methodology 49549-9

For Providers

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf