HLA A CWD Resolution

CPT: 81380
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Test Details


  • CWD Resolution Typing


Test provides data for clients to use for matching transplant donors and recipients. Specific HLA A alleles may be correlated with certain disease states or other clinical conditions. This test may be used to identify specific alleles (except for HLA A*02:01 [167107]).

CWD resolution typing for HLA will meet the following criteria:

1. The typing must contain only one unambiguously assigned genotype, or

2. The typing may contain multiple alternative genotypes if one includes two Common and Well Documented (CWD) alleles and the others do not include any CWD allele. Alleles that encode identical protein sequences in the antigen recognition site (ARS) will not be resolved even if they are CWD.

3. Rare or unusual allele combinations may not be ruled out.

4. Allele codes will be reported to include those alleles that are not ruled out.

Common and well documented alleles are defined by Cano et al1 and Mack et al.2


This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.

Specimen Requirements


Whole blood


7 mL

Minimum Volume

3 mL


Lavender-top (EDTA) tube

Storage Instructions

Maintain specimen at room temperature; protect from extreme heat or cold. Do not freeze.

Causes for Rejection

Hemolyzed specimen; clotted specimen; wrong specimen container

Clinical Information

Special Instructions

If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.


1. Cano P, Klitz W, Mack SJ, et al. Common and well-documented HLA alleles: Report of the ad-hoc committee of the American Society for Histocompatibility and Immunogenetics. Hum Immunol. 2007 May; 68(5):392-417. 17462507
2. Mack SJ, Cano P, Hollenbach JA, et al. Common and Well-Documented HLA Alleles: 2012 Update to the CWD Catalogue. Tissue Antigens. 2013 Apr; 81(4):194-203. 23510415


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
167331 HLA-A (CWD) 019414 HLA-A 13298-5
167331 HLA-A (CWD) 019415 HLA-A 13298-5
167331 HLA-A (CWD) 167384 HLA Methodology 49549-9

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf